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Stage Information for Prostate Cancer

    Table 3. Definitions of TNM Stage III

    StageTNMDescription
    T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; G = Histopathologic grade.
    Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
    The explanations for superscripts a and c are at the end ofTable 4.
    IIIT3, N0, M0, any GT3 = Tumor extends through the prostate capsule.c
    N0 = No regional lymph node metastasis.
    M0 = No distant metastasis.a
    GX = Grade cannot be assessed.
    G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
    G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
    G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).

    Table 4. Definitions of TNM Stage IV

    StageTNMDescription
    T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; G = Histopathologic grade; p = Pathologic.
    Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
    a When more than one site of metastasis is present, the most advanced category (pM1c) is used.
    b Tumor found in one or both lobes by needle biopsy, but not palpable or reliably visible by imaging, is classified as T1c.
    c Invasion into the prostatic apex or into (but not beyond) the prostatic capsule is classified not as T3 but as T2.
    IVT4, N0, M0, any GT4 = Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.
    N0 = No regional lymph node metastasis.
    M0 = No distant metastasis.a
    GX = Grade cannot be assessed.
    G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
    G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
    G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
    Any T, N1, M0, any GTX = Primary tumor cannot be assessed.
    T0 = No evidence of primary tumor.
    T1 = Clinically inapparent tumor not palpable or visible by imaging.
    T1a = Tumor incidental histologic finding in ≤5% of tissue resected.
    T1b = Tumor incidental histologic finding in >5% of tissue resected.
    T1c = Tumor identified by needle biopsy (e.g., because of elevated PSA).
    T2 = Tumor confined within prostate.b
    T2a = Tumor involves ≤50% of one lobe.
    T2b = Tumor involves >50% of one lobe but not both lobes.
    T2c = Tumor involves both lobes.
    T3 = Tumor extends through the prostate capsule.c
    T3a = Extracapsular extension (unilateral or bilateral).
    T3b = Tumor invades seminal vesicle(s).
    T4 = Tumor is fixed or invades adjacent structures other than seminal vesicles such as the bladder, external sphincter, rectum, levator muscles, and/or pelvic wall.
    N1 = Metastasis in regional lymph node(s).
    M0 = No distant metastasis.a
    GX = Grade cannot be assessed.
    G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
    G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
    G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
    Any T, any N, M1, any GTX = Primary tumor cannot be assessed.
    T0 = No evidence of primary tumor.
    T1 = Clinically inapparent tumor not palpable or visible by imaging.
    T1a = Tumor incidental histologic finding in ≤5% of tissue resected.
    T1b = Tumor incidental histologic finding in >5% of tissue resected.
    T1c = Tumor identified by needle biopsy (e.g., because of elevated PSA).
    T2 = Tumor confined within prostate.c
    T2a = Tumor involves ≤50% of one lobe.
    T2b = Tumor involves >50% of one lobe but not both lobes.
    T2c = Tumor involves both lobes.
    T3 = Tumor extends through the prostate capsule.c
    T3a = Extracapsular extension (unilateral or bilateral).
    T3b = Tumor invades seminal vesicle(s).
    T4 = Tumor is fixed or invades adjacent structures other than seminal vesicles such as the bladder, external sphincter, rectum, levator muscles, and/or pelvic wall.
    NX = Regional lymph nodes were not assessed.
    pNX = Regional nodes not sampled.
    N0 = No regional lymph node metastasis.
    pN0 = No positive regional nodes.
    N1 = Metastasis in regional lymph node(s).
    pN1 = Metastases in regional node(s).
    M1 = Distant metastasis.a
    M1a = Nonregional lymph node(s).
    M1b = Bone(s).
    M1c = Other site(s) with or without bone disease.
    GX = Grade cannot be assessed.
    G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
    G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
    G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
    1|2|3|4|5|6|7

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