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Prostate Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Prostate Cancer

Table 5. Pathologic (pT)a,b

p = Pathologic; T = Primary tumor.
Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
a There is no pathologic T1 classification.
b Positive surgical margin should be indicated by an R1 descriptor (residual microscopic disease).
pT2Organ confined.
pT2aUnilateral, ≤½ of one side.
pT2bUnilateral, involving >½ of side but not both sides.
pT2cBilateral disease.
pT3Extraprostatic extension.
pT3aExtraprostatic extension or microscopic invasion of bladder neck.b
pT3bSeminal vesicle invasion.
pT4Invasion of rectum, levator muscles, and/or pelvic wall.

Table 6. Anatomic Stage/Prognostic Groupsa

GroupTNMPSA ng/mlGleason
T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; PSA = Prostate-specific antigen.
Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
a When either PSA or Gleason is not available, grouping should be determined by T stage and/or either PSA or Gleason as available.
IT1a–cN0M0PSA <10Gleason ≤6
T2aN0M0PSA <10Gleason ≤6
T1–2aN0M0PSA XGleason X
IIAT1a–cN0M0PSA <20Gleason 7
T1a–cN0M0PSA ≥10 <20Gleason ≤6
T2aN0M0PSA <20Gleason ≤7
T2bN0M0PSA <20Gleason ≤7
T2bN0M0PSA XGleason X
IIBT2cN0M0Any PSAAny Gleason
T1–2N0M0PSA ≥20Any Gleason
T1–2N0M0Any PSAGleason ≥8
IIIT3a–bN0M0Any PSAAny Gleason
IVT4N0M0Any PSAAny Gleason
Any TN1M0Any PSAAny Gleason
Any TAny NM1Any PSAAny Gleason

Table 7. Prognostic Factors (Site-Specific Factors)

Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
Required for stagingPSA.
Gleason score.
Clinically significantGleason primary and secondary patterns.
Gleason tertiary pattern.
Clinical staging procedures performed.
Number of biopsy cores examined.
Number of biopsy cores positive for cancer.
1|2|3|4|5|6

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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