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Relapsing MS Symptom Overview

Relapses vs Symptoms

Relapses are not the same as symptoms. While MS symptoms such as fatigue, muscle stiffness, pain, and depression can last a long time and never get completely better, relapses are periods of time when symptoms get worse or new symptoms appear. These usually occur suddenly, last for days or weeks, and usually get better, at least partially.

Symptoms of MS

MS Symptoms (Click on any of these topics for more information):

When to Call Someone about Your Symptoms

Sometimes, a symptom is urgent and you should contact a health care provider right away. Remember to check with your doctor about when you should call.

Some reasons to call include:

  • You experience a new MS symptom that lasts at least 24 hours
  • You experience loss of vision or blurry vision
  • You have an abrupt change in bowel or bladder function
  • You think you have a urinary tract infection
  • You have feelings of depression or thoughts of hurting yourself

Keep in mind that this is not a complete list.

If you experience worsening depression or have thoughts of hurting yourself, contact your doctor immediately.

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Abnormal Feelings and Sensations

Many people with MS experience abnormal sensations. While frustrating, most of these symptoms don't affect physical function and can be managed or treated.

Abnormal sensations may include:

  • Pins and needles/Tingling
  • Itching
  • Burning
  • Numbness

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Bowel or Bladder Problems

The most common bowel problem in people with MS is constipation. Bladder problems can vary and may include:

  • Increased need to urinate
  • Hesitancy in starting urination
  • Urgency to urinate right away
  • Frequent nighttime urination
  • Leaking Incontinence (an inability to hold urine in the bladder)

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Depression or Mood Swings

Depression is a serious condition that appears to be more common in people living with MS. If you experience symptoms of depression or have thoughts of death or suicide, contact your doctor immediately.

Symptoms of depression include:

  • Sadness
  • Loss of interest or pleasure in everyday activities
  • Loss of or increase in appetite
  • Insomnia or sleeping too much
  • Agitation or slowing in behavior
  • Fatigue (feeling of tiredness)
  • Feelings of worthlessness or guilt
  • Problems with thinking or concentration
  • Ongoing thoughts of death or suicide

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Fatigue

Fatigue is one of the most common symptoms, occurring in nearly 80% of people with MS. Fatigue can feel like sleepiness or lack of physical or mental energy. It is often described as exhaustion that is not caused by activity and not relieved by rest.

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Heat Sensitivity

The symptoms of MS often worsen with increased body temperature. This can be caused by factors such as intense exercise, fever, sun exposure, or even sitting in a hot tub.

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Issues with Memory, Attention, or Problem Solving

Many people with MS experience problems with memory, attention, or problem solving. These are called "cognitive" issues. Memory loss is the most common mental change in MS.

Some examples of memory loss are:

  • Forgetting names, telephone numbers, or recent conversations
  • Difficulty remembering what you just learned
  • Not knowing why you entered a room
  • Losing or misplacing things

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Muscle Stiffness or Spasms (Spasticity)

Stiffness may feel like muscle tightness and may not be painful. Or stiffness may be severe enough to produce painful, uncontrollable spasms. Spasticity occurs most often in the upper and lower extremities.

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Pain

More than half of the people with MS say that pain is a problem. Some types of pain common in MS include:

  • Trigeminal neuralgia (tri-GEM-in-uhl noor-AL-juh): a stabbing pain in the face. It can occur as an initial symptom of MS. It can also be confused with dental pain
  • Lhermitte's (lair-MEETS) sign: a brief, stabbing, electric shock-like feeling that runs from the back of the head and down the spine. It can be triggered by bending the neck forward
  • Pain of spasticity: tightness or aching in joints and painful muscle spasms or cramps may occur (see section on muscle pain or stiffness for more information)
  • Back and other musculoskeletal pain, especially lower back pain, can have many causes. They include:
    • Spasticity
    • Pressure on the body caused by lack of movement
    • Incorrect use of mobility aids
    • Poor walking posture, unusual walking pattern, and balance problems

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Sexual Issues

In women, symptoms include:

  • Reduced sensation in the genital area or painfully heightened sensation
  • Vaginal dryness
  • Trouble achieving orgasm
  • Loss of desire

In men, symptoms include:

  • Difficulty achieving or maintaining an erection (the most common problem)
  • Reduced sensation in the penis
  • Difficulty achieving orgasm or ejaculation
  • Loss of desire

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Vision Problems

Vision problems are common in people with MS, but are usually temporary.

Some types of vision problems are:

  • Optic neuritis: inflammation of the optic nerve, which may result in blurring or graying of vision, a dark spot in the center of your visual field, or rarely, blindness in one eye
  • Nystagmus (nuh-STAG-miss): uncontrolled horizontal or vertical eye movements, which may result in impaired vision
  • Double vision: occurs when the muscles that control a particular eye movement are weak

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Walking and Balance Problems

Problems with walking (also known as gait) are fairly common in MS.

Some examples include:

  • Foot drop: difficulty turning the ankle and toes upward, resulting in the foot slapping the floor
  • Toe drag: weakness or inability to extend or flex the toes
  • Ataxia: swaying, unsteady gait caused by loss of balance
  • Numbness can occur in the feet. Numbness can make you unable to feel the floor or know where your feet are

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Weakness

In MS, weakness can be a result of a problem with a nerve signal. You may also experience weakness from lack of activity. Sometimes you may be less active because of fatigue, stiffness, or a relapse. The longer you are inactive, the weaker your muscles can become.

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Indication

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for treatment of chronic progressive MS. Rebif is available in 22 mcg and 44 mcg prefilled, preassembled syringes and a titration pack.

Important safety information

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, or blood cell count or bleeding problems, or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression and risk of suicide, liver problems, risk to pregnancy, injection-site problems, and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty in breathing and loss of consciousness, which require immediate medical attention.

The most common side effects with Rebif are injection-site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, elevated liver enzymes, and blood abnormalities.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your doctor. For additional information about Rebif, please consult the Medication Guide and talk to your doctor. You can also visit www.mslifelines.com or call toll-free 1-877-447-3243. Rebif is available by prescription only.

Rebif and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

Brought to you by EMD Serono, Inc. and Pfizer Inc, the co-marketers of
Rebif® (interferon beta-1a) in the US.
EMD Serono / Pfizer

Prescribing Information (PDF) - Medication Guide (PDF)

This information is intended only for residents of the United States.

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