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    Biologics for Juvenile Idiopathic Arthritis


    Generic Name Brand Name
    abatacept Orencia
    adalimumab Humira
    etanercept Enbrel
    infliximab Remicade
    tocilizumab Actemra

    How It Works

    Biologics block harmful responses from the body's immune system that lead to the symptoms of juvenile idiopathic arthritis (JIA).

    Why It Is Used

    Biologics are used to treat moderate to severe JIA symptoms and to prevent joint damage, particularly in people who have had side effects or poor results from methotrexate treatment.

    Biologics are usually used after nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and methotrexate have been tried. A biologic is often used at the same time as these other medicines, especially to treat polyarticular JIA and extended oligoarticular JIA.1

    Biologics may also be tried when eye inflammation has not improved after trying other drugs such as corticosteroids and mydriatics.

    How Well It Works

    Etanercept is most widely studied for juvenile idiopathic arthritis. In general, biologics improve symptoms, help prevent bone and cartilage damage, and may even help with healing.2

    Side Effects

    All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine your child takes. Side effects are also listed in the information that comes with the medicine.

    Here are some important things to think about:

    • Usually the benefits of the medicine are more important than any minor side effects.
    • Side effects may go away after your child takes the medicine for a while.
    • If side effects still bother your child and you wonder if he or she should keep taking the medicine, call your doctor. He or she may be able to lower the dose or change the medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

    Call911or other emergency services right away if your child has:

    Call your doctor right away if your child has:

    • Hives.
    • Signs of illness or infection, such as chills, cough, or fever.
    • A rash on his or her head, face, or belly.

    Common side effects of this medicine include:

    See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

    What To Think About

    Warnings about serious side effects of biologics have been issued. The U.S. Food and Drug Administration (FDA) and the drug's manufacturers have warned about:

    • An increased risk of a serious infection. Biologics affect the body's ability to fight all infections. So if your child gets a fever, cold, or the flu while he or she is taking this medicine, let the doctor know right away.
    • An increased risk of blood or nervous system disorders. Call the doctor if your child has symptoms of blood disorders (such as bruising or bleeding) or symptoms of nervous system problems (such as numbness, weakness, tingling, or vision problems).
    • An increased risk of lymphoma (a type of blood cancer) in children and adolescents who take this medicine for longer than 2½ years (30 months). Adults, children, and adolescents who take this medicine also have a higher risk for leukemia and other cancers.
    • An increased risk of psoriasis.
    • An increased risk of liver injuries. Call the doctor if your child's skin starts to look yellow, if he or she is very tired, or if your child has a fever and dark brown urine.

    Taking medicine

    Medicine is one of the many tools your doctor has to treat a health problem. If your child takes medicine as your doctor suggests, it will improve your child's health and may prevent future problems. If your child doesn't take the medicines properly, his or her health (and perhaps life) may be at risk.

    There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.


    Follow-up care is a key part of your child's treatment and safety. Be sure to make and go to all appointments, and call your doctor if your child is having problems. It's also a good idea to know your child's test results and keep a list of the medicines your child takes.

    Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.


    1. Weiss JR, Ilowite NT (2005). Juvenile idiopathic arthritis. Pediatric Clinics of North America, 52(2): 413-442.

    2. Soep JB (2011). Rheumatic diseases. In WW Hay et al., eds., Current Diagnosis and Treatment: Pediatrics, 20th ed., pp. 825-831. New York: McGraw-Hill.

    ByHealthwise Staff
    Primary Medical ReviewerSusan C. Kim, MD - Pediatrics
    Specialist Medical ReviewerJohn Pope, MD - Pediatrics

    Current as ofSeptember 9, 2014

    WebMD Medical Reference from Healthwise

    Last Updated: September 09, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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