Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

Rheumatoid Arthritis (RA) and Diabetes

Understanding the RA/diabetes connection.
WebMD Feature
Reviewed by Louise Chang, MD

There’s research that suggests a connection between rheumatoid arthritis (RA) and diabetes. But the nature of that connection or even whether it’s actually real is unclear. "There are tantalizing links between the two diseases,” says Daniel Solomon, MD, MPH, an associate professor of medicine at Harvard Medical School and a rheumatologist at Brigham and Women's Hospital in Boston. But "at this point they are mainly speculative."

WebMD asked Solomon and Androniki Bili, MD, MPH, to explore the possible connection between RA and diabetes. Bili is an associate rheumatologist at Geisinger Health System in Danville, Pa. Here is what they had to say and how it might affect the way you manage RA.

RA/Diabetes Connection: What Are the links?

There are a number of theories about the connection between diabetes and rheumatoid arthritis. RA is an autoimmune disease. The immune system defends the body from invading organisms and substances that can cause damage. With RA, the body’s immune system attacks its own joints. The result of that attack is an ongoing inflammation, which is a hallmark of RA. Some research suggests that inflammation may also play a role in the onset of diabetes.

Solomon tells WebMD that there are links between inflammation and insulin resistance. "We know there is an increased risk of insulin resistance among people with RA," he says. Insulin is produced in the pancreas and helps the body use glucose, or blood sugar, for energy. In people with insulin resistance, the body’s cells don’t respond to insulin in the correct way. That increases the risk of developing type 2 diabetes.

But inflammation is not the only potential link between RA and diabetes. Certain drugs that are used to treat RA, namely steroids, may actually increase the risk of diabetes. "We need to be very aware of RA patients' glucose levels, especially if they are on corticosteroids,” says Solomon. “This drug is a risk factor for hyperglycemia or high blood sugar levels."

The effects of RA may also increase the risk of diabetes. People with RA may lead sedentary lives due to pain and RA-related disabilities. When people are physically inactive, they are more likely to be overweight. Being overweight or obese is a known risk factor for diabetes. And according to the CDC, the inactivity caused by arthritis interferes with management of both RA and diabetes.

1 | 2 | 3

Today on WebMD

rubbing hands
Avoid these 6 common mistakes.
mature couple exercising
Decrease pain, increase energy.
mature woman threading needle
How much do you know?
Swelling, fatigue, pain, and more.
Lucille Ball
Hand bones X-ray
prescription pills
Woman massaging her neck
woman roasting vegetables in oven
Woman rubbing shoulder
Working out with light weights