Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

New Remicade Warning.

Arthritis, Crohn's Disease Drug Linked to Rare but Deadly Liver Failure
WebMD Health News

Dec. 23, 2004 -- Remicade is linked to rare but sometimes deadly liver reactions, drug maker Centocor and the FDA announced Wednesday.

Remicade is approved to treat rheumatoid arthritis and Crohn's disease.

In a "Dear Healthcare Professional" letter, Centocor is warning doctors that patients treated with Remicade have developed acute liver failure and other liver problems, including jaundice.

Some patients died or required liver transplants to save their lives. The liver reactions occurred two weeks to more than a year after Remicade treatment. Lab tests for abnormal liver enzymes -- a standard test for liver trouble -- did not always predict these liver reactions.

These events appear to be quite rare. They've been reported in three patients before Remicade approval, and in 35 patients worldwide since the drug has been approved. In that time, some 576,000 patients have been treated with Remicade.

Remicade works by suppressing the immune system. That's helpful to patients whose overactive immune reactions underlie their rheumatoid arthritis, Crohn's disease, or ankylosing spondylitis. But it can also be a problem. Remicade treatment has been previously linked to serious infections including tuberculosis. Some of these infections have been fatal.

The Centocor letter also notes that a warning about risk of pneumonia has been added to the Remicade label.

Liver Failure Symptoms

Patients taking Remicade should be aware of symptoms of liver damage or failure, which include:

Today on WebMD

rubbing hands
Avoid these 6 common mistakes.
mature couple exercising
Decrease pain, increase energy.
mature woman threading needle
How much do you know?
Swelling, fatigue, pain, and more.
Lucille Ball
Hand bones X-ray
prescription pills
Woman massaging her neck
woman roasting vegetables in oven
Woman rubbing shoulder
doctor and patient hand examination