Aug. 11, 2010 -- A new way of classifying rheumatoid arthritis should lead to earlier identification of the disease, which, in turn, should help investigators explore new therapies to prevent its ravages, researchers say.
The revised classification, announced this week by the American College of Rheumatology and the European League Against Rheumatism, will allow researchers to recruit patients for clinical trials earlier in the disease process, says Boston University associate professor of medicine and epidemiology Tuhina Neogi, MD, PhD.
It may also lead to earlier treatment of some patients with suspected rheumatoid arthritis (RA), she says, although that was not the purpose of the revision.
The new criteria appear in the September issue of Arthritis & Rheumatism.
"It is likely that this will be adopted into clinical practice, but many other factors must be considered for a diagnosis of rheumatoid arthritis," Neogi tells WebMD. "The rheumatologist has to take into account the patient's specific risk factors and a whole host of other things. The process is very nuanced."
An estimated 1.3 million people in the U.S. have rheumatoid arthritis. The disease strikes twice as many women as men.
RA is a progressive disease, mainly characterized by inflammation of the lining of the joints, but it can also affect other organs.
Early diagnosis of RA is complicated by the fact that its symptoms mimic those of other common conditions including osteoarthritis, gout, lupus, and infection-related joint inflammation.
It has been almost 25 years since the classification criteria for RA has been updated. Since that time much has been learned about the disease and new treatments have been introduced that can prevent the joint damage and bone erosion characteristic of advanced RA.
Under the old classification system many patients did not meet the definition for RA until joint damage was evident.
"The goal of today's treatments is to keep people from reaching the point where they have bone erosion and joint deformities," Neogi says.
Morning Stiffness Not Specific to RA
Under the new system, patients with inflamed joint linings with no other obvious cause will be evaluated for RA using a 10-point analysis that includes such factors as symptom duration and the number and size of the joints involved.