Revving Up Women's Sex Drive
Will there ever be a 'Viagra' for women?
Shifren and colleagues recently tested testosterone patches on
women who underwent menopause naturally and were taking estrogen therapy. The
results of that study are expected in the fall. In addition, a trial of
testosterone on menopausal women, not on estrogen therapy, is about to
If all goes well, and the FDA gives its approval, the
testosterone patch could be available in one to two years.
Some women use testosterone products designed for men, but
these products have not been tested in large studies in women, and could have
10 times more hormones than women need, says Mary Lake Polan, MD, PhD, MPH,
professor and chair of ob-gyn at Stanford University School of Medicine in
Too much testosterone in women could have masculinizing
effects, such as hoarseness or deepening of the voice, unnatural hair growth or
loss, acne or oily skin, decreased breast size, increase in the size of female
genitals, and irregular menstrual cycles.
Additionally, other forms of testosterone such as creams and
gels do not have conclusive evidence that they work to boost women's
There is one FDA-approved androgen (male hormone) on the market
for women. Estratest is a combination of oral estrogen and testosterone.
Although the product is only approved to treat
estrogen-resistant hot flashes, it has been used "off-label" by doctors and
patients. Off-label use means physicians prescribe drugs for a purpose other
than what they are approved for.
Estratest has not been approved to improve sexual desire in
menopausal women, but double-blind trials have shown it can do the job, says
Shifren. "The nice thing is that it is a pharmacy-grade product designed for
women. So there are a lot of data on safety and efficacy."
The drawback is that the drug is a fixed dose of a combination
of estrogen and androgen. Women who may not need estrogen for hot flashes may
not want to use the product.
"Estratest would be a very appropriate therapy for surgically
menopausal women who, after surgery, notice hot flashes and a decrease in
[sexual] desire," says Shifren.