Testosterone replacement therapy has been used since the 1940s. Injections, usually given every few weeks, are one of the oldest ways to increase testosterone. Gels are used widely in the U.S. They are applied daily to the shoulder, abdomen, or upper arm. The general goal of treatment is to raise the blood testosterone level only into the mid-normal range -- about 400-700 ng/dL. Other methods include patches, oral adhesive tablets and TESTOPEL (testosterone pellets), which is a pellet that is injected subcutaneously and can last 3-6 months.