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Heart, Stroke Risk Low With Birth Control Pills

No-Estrogen and Lowest-Estrogen Contraceptives Safest, Study Finds
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Two-Fold Increase in Risk continued...

Use of combined oral contraceptives with ultra-low doses of estrogen (20 mcg) was associated with a 50% increase in risk, while use of traditional low-dose pills (30 to 40 mcg) was associated with an 80% increase in risk.

Overall, the study shows that heart attacks and strokes caused by blood clots were twice as likely in women using combination oral contraceptives. But the risk is still very low for most women, especially those younger than 35 with few risk factors for these events, Lidegaard tells WebMD.

"A 20-year-old with a very low baseline risk for heart attack and stroke should not be all that concerned that her risk may be double, but a woman who is 35 or older with 10 times the baseline risk may want to choose another form of birth control."

Progestin-Only IUD Appears Safest

He adds that progestin-only contraceptives, which appear to convey no increased risk at all, may be a good choice for these women.

In an editorial published with the study, Arizona State University researcher Diana B. Petitti, MD, MPH, writes that the Danish study should reassure women and their doctors about the safety of oral contraceptives.

She notes that the small increase in risk could perhaps be eliminated if women with risk factors for heart attack and stroke, such as smokers and those with high blood pressure, avoided combination hormonal contraceptives.

The FDA recommends against the use of combination oral contraceptives in women over age 35 who smoke.

Petitti tells WebMD that these women and older women who are obese or have high blood pressure should be cautious, but she adds that most women who take oral contraceptives have little to worry about.

"We know a lot about who is at risk for these events," she says. "Women should have their blood pressure checked before starting a combined contraceptive, and if they have hypertension they should probably use another form of birth control."

The finding that progestin-only hormonal birth control does not raise arterial blood clot risk should be particularly reassuring to older women, notes Kathy Hoeger, MD, chief of the reproductive endocrinology division at the University of Rochester and director of the Strong Fertility Center.

"Just like younger women, women in their late 30s and 40s need reliable and safe contraception," she tells WebMD.

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