Cosmetic Fillers: A Quick Way to End Wrinkles
Wrinkles may be proof of wisdom. But do you ever wish you didn't have to look quite so wise?
Cosmetic fillers are materials injected underneath the skin to make it fuller. After injection, the plumper skin shows fewer wrinkles and looks younger.
Injectable cosmetic fillers have been around for decades. In recent years, medical advances have brought new versions of this wrinkle treatment to the marketplace. Newer cosmetic fillers are longer lasting, even permanent -- but do your homework before heading to the cosmetic surgeon.
The Birth of a Wrinkle
Skin is held tight and smooth by three critical components: collagen, hyaluronic acid, and elastin. These chemicals combine to create a firm, spongy meshwork under the skin surface. This elastic structure keeps the skin surface smooth and firm.
We slowly lose the integrity of the meshwork as we age. With weakness in the underlying support structure, the skin's surface loses its perfect baby-skin smoothness.
Injecting cosmetic fillers helps fill the thinned-out meshwork. They plump up the tissue underneath skin, shrinking wrinkles. The skin becomes firmer, smoother, and younger-looking.
Collagen is the oldest and best-known cosmetic filler. Newer natural and synthetic products are available, each with its own advantages and disadvantages.
Bovine Collagen Fillers
Bovine collagen is processed from the skin of cows. Approved in the 1980s as a wrinkle treatment, bovine collagen is still in wide use as a cosmetic filler.
Bovine collagen is effective, and less expensive than other treatments. It can cause allergic reactions, so allergy skin testing is generally done before beginning the injections.
Collagen injections are broken down naturally by the body. Injections need to be repeated two to four times per year to maintain results.
Human Collagen Fillers
Human collagen, mass-produced from cultures of human cells, became available in 2002. Human collagen causes dramatically fewer allergic reactions, so skin testing is usually not needed. It is more expensive than bovine collagen, and injections also need to be repeated every three to six months.
Hyaluronic Acid Fillers
Hyaluronic acid is a naturally occurring polysaccharide (chain of sugars). It's a normal part of the support structure under the skin. Age depletes hyaluronic acid in the skin, but injections can replace it.
Various natural and synthetic hyaluronic acid (HA) products are available. In the newest products, the HA molecule is modified to break down more slowly. Cosmetic results can last nine months or longer. Allergic reactions are very rare.
Fat Injection Fillers
Ever wish you could move that fat from your thighs to somewhere it might look a little better? Fat injections involve removing small amounts of fat from the thighs, belly, or buttocks and injecting it under the skin of the face. The fat expands the skin, shrinking wrinkles. Because it is the patient's own tissue, there can be no allergic reaction. Results are variable, and are sometimes permanent.
WebMD Medical Reference
VIVELLE-DOT (estradiol transdermal system) IS AVAILABLE BY PRESCRPTION ONLY.
INDICATION
Vivelle-Dot is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; help reduce your chances of getting osteoporosis (thin weak bones); and treat certain conditions in which a young woman's ovaries do not produce enough estrogens naturally. Vivelle-Dot 0.025 mg/day is only used to prevent osteoporosis from menopause. If you use Vivelle-Dot only to treat your dryness, itching, and burning in and around your vagina or if you use Vivelle-Dot only to prevent osteoporosis from menopause, talk with your healthcare professional about whether a different treatment or medicine without estrogens might be better for you.
IMPORTANT SAFETY INFORMATION
Estrogens increase the chances of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with progestins may increase your risk of dementia (decline in memory and thinking skills).
Vivelle-Dot should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.
The most common side effects that may occur with Vivelle-Dot are headache, breast tenderness, and back pain.
You and your healthcare professional should talk regularly about whether you still need treatment with Vivelle-Dot.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Full Prescribing Information for Vivelle-Dot.

