Botox Injections Fight Underarm Sweat
Botox Treatment May Offer Long-Term Relief From Hyperhidrosis
July 26, 2005 -- A treatment made famous for fighting wrinkles may also
provide lasting relief from another embarrassing condition: excessive underarm
The first long-term study of Botox injections in the treatment of the common
sweating disorder shows the injections can safely reduce underarm sweat for up
to two years.
Known in medical terms as axillary hyperhidrosis, the condition affects more
than a million people in the U.S. People with this condition sweat up to four
times more than normal in order to maintain a normal body temperature.
People with the disorder often suffer from difficulty in social situations
and say it significantly interferes with their daily activities.
"These long-term data demonstrate that Botox for severe primary axillary
hyperhidrosis over a two-year period is a safe and effective therapeutic option
for patients who otherwise struggle with substantial impairment," says
researcher Dee Anna Glaser, MD, professor of dermatology and vice chairman of
dermatology at Saint Louis University School of Medicine, in a news
The that can't be resolved with
prescription creams or antiperspirants in July 2004.
Botox Offers Lasting Relief
In this three-year study, researchers examined the safety, effectiveness,
and cost of repeated treatment with Botox injections on people with axillary
hyperhidrosis and the impact of the treatment on their quality of life.
The study involved 193 people who had participated in an earlier one-year
clinical trial of Botox for hyperhidrosis. They were given the option to
continue treatment every eight weeks if symptoms persisted under this follow-up
In the follow-up study, researchers found Botox continued to be effective
with repeated treatment. After the first treatment, 82% had up to a 75%
reduction in sweat production in four weeks after the injection.
Four weeks after treatments two and three, 79% experienced the same degree
Overall, 94% of patients required four or fewer Botox injections to control
their symptoms during the two-year study.
Botox May Ease Social Stigma of Sweat
The study also found that the treatment had a positive effect on the
patients' quality of life, for example:
- Before treatment, 66%-72% of patients were somewhat or very dissatisfied
with their ability to perform their current work activities, compared with
9%-20% after treatment.
- The number of patients who reported feeling "emotionally damaged or
injured" due to their hyperhidrosis reduced by about half before and after
treatment, from 76%-83% to 32%-42%.
- Participants reported significantly less limitation in interpersonal and
social situations. Before treatment 17%-33% said they were somewhat or very
satisfied with their ability to perform nonwork activities. After treatment,
that proportion increased to 78%-88%.
Glaser presented the results of the study this week at a meeting of the
American Academy of Dermatology in Chicago. Funding for the study was provided
by Allergan, Inc., which produces Botox.