Erythema infectiosum (fifth disease). Erythema infectiosum is a mild childhood disease that is caused by human parvovirus B19. This condition develops after a mean incubation period of 14 days. There are few if any prodromal symptoms. The rash evolves in three clinical stages. The first stage is characterized by the abrupt appearance of a bright-red malar blush. The appearance is so startling that it has been given the suggestive description of “slapped cheeks”. During the second stage, the facial rash begins to fade, and a maculopapular, urticarial, or morbilliform exanthem develops on the extremities and trunk. Pruritus may be present.
Color Atlas of Pediatric Dermatology
Samuel Weinberg, Neil S. Prose, Leonard Kristal
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