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Childhood Skin Problems
Neurofibromatosis
Neurofibromatosis (von Recklinghausen’s disease). This autosomal dominant disorder includes a number of distinctive cutaneous findings and a wide variety of neurologic manifestations. This picture shows a café-au-lait spot. Solitary lesions of this type are common in normal individuals; most patients with neurofibromatosis have more than a single macule. The presence of more than six lesions that are larger than 0.5cm in diameter in prepubescent children and 1.5 cm in diameter in adults is considered one of the major diagnostic criteria for this disease.
Color Atlas of Pediatric
Dermatology
Samuel Weinberg, Neil S. Prose, Leonard Kristal
Copyright 2008, 1998, 1990, 1975, by the McGraw-Hill Companies, Inc. All rights
reserved.
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