Psoriasis: When Should You Consider a Biologic?

From the WebMD Archives

When you have psoriasis, often you and your doctor will try a few treatments before finding one that really clears your skin. If you've already tried a few medicines and nothing has worked, your doctor may recommend a biologic drug.

Other drugs you may have taken are made from plants or chemicals. Biologics are made from proteins. They target the immune response that leads to the rapid skin cell growth of psoriasis.

Examples of biologic drugs include:

Biologics are potent psoriasis treatments. They work well to treat moderate or severe psoriasis, says Mark Lebwohl, MD, chairman of the National Psoriasis Foundation Medical Board, and he says he prefers them over other psoriasis drugs.

But they also have two key drawbacks:

  • Biologic drugs are expensive. Depending on the drug and the dose, they can cost $10,000 to $30,000 a year.
  • Biologics suppress the immune system. That means they can increase the risk for infection.

Here are some reasons why your doctor might -- or might not -- prescribe a biologic drug for your psoriasis.

Should You Consider a Biologic?

Whether you should consider a biologic drug depends on five factors, says Lebwohl.

  1. How much of your skin is affected
  2. How much psoriasis affects your life
  3. Your health
  4. Whether your insurance company will cover the cost
  5. Your preferences

1. How Much of Your Skin is Affected by Psoriasis

Doctors often use biologic drugs on people with moderate-to-severe psoriasis.

  • Moderate psoriasis means that 3% to 10% of your body is covered with red, scaly patches.
  • Severe psoriasis means that more than 10% of your body is covered.

You may also want to take a biologic drug if you have mild psoriasis but it really bothers you.

2. How Much Psoriasis Impacts Your Life

"One of the most important factors is how much the psoriasis actually bothers the patient. I have patients who want to start a biologic ... even if the psoriasis is in an extremely limited surface area," says Jenny Murase, MD. She's an assistant clinical professor at the University of California, San Francisco and a practicing dermatologist with the Palo Alto Medical Foundation.