July 25, 2001 -- For people with severe psoriasis, the treatments can be as bad as the disease. But several new therapies currently being studied offer hope of a more targeted and less risky approach to coping with the disease.
Psoriasis, which affects approximately 1-3% of the world's population, is a skin disease that appears as patches of raised red skin covered by a flaky white buildup. It's thought to be related to faulty signals sent by the body's immune system, although the exact cause is unknown.
But new agents that specifically target cells that contribute to the skin condition are proving to be very effective at controlling the disease, and doing so with few side effects.
"For the first time we are in a position to treat these most serious cases of psoriasis over the long term with a therapy that has an excellent safety profile," Charles N. Ellis, MD, professor and chief of dermatology at the University of Michigan Health Systems, tells WebMD. "Psoriasis is a terrible thing to have, but it is not usually life-threatening. So a drug's safety profile is critical."
In the July 26 issue of the New England Journal of Medicine, Ellis and colleagues report that the experimental drug Amevive, made by Biogen, is effective and well tolerated in the treatment of patients with moderate to severe chronic plaque psoriasis, the most common form of the skin disorder.
In the study, 229 patients received 12 weeks of injections with either Amevive or an identical-looking placebo. They were then monitored for an additional 12 weeks. At the end of the follow-up period, approximately one out of four patients who got the new drug had complete, or nearly complete, clearing of their psoriasis. Three patients on placebo had similar results, but those three had also received additional treatment.
Patients were able to go about 10 months before needing a second course of treatment.