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Drug May Cut Psoriasis Depression

Depression, Fatigue Eased in Study of Arthritis Drug, Enbrel

Side Effects

The most common side effects were reactions at the injection sites. Infections were more common in the Enbrel group but not by much, the researchers note.

No patients became suicidal during the study. If any had become suicidal, those patients would have been removed from the study and given psychiatric care.

Surprising Data

"Surprisingly, the majority of patients in this study did not have significant depression at baseline, by contrast with what is known about the general psoriasis population," write Tyring and colleagues.

They suggest that the study's design might partly explain that. Patients were excluded if they had a history of psychiatric disorders that might interfere with study participation.

The study was partly designed by Immunex, which invented Enbrel. Immunex and Wyeth Research funded the study. Amgen, which now owns Immunex, provided "editorial assistance" in writing the paper, the researchers write.

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