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    Some medications make your psoriasis worse, but your doctor may be able to suggest other treatments that can manage your health problems without causing flare-ups.

    Check your medicine cabinet to see if you're taking any of these drugs:

    Blood Pressure Meds

    If you have high blood pressure, you might be taking a drug that slows your heart rate. You may hear your doctor call it a "beta-blocker." Doctors don't know whether all meds in this group make psoriasis worse, but a few have been linked to flares, including:

    • Atenolol (Tenormin)
    • Metoprolol (Lopressor, Toprol XL)
    • Propranolol (Hemangeol, Inderal, InnoPran XL)

    Ask your doctor if you can switch to a medicine that won't affect your skin condition.


    That stands for nonsteroidal anti-inflammatory drugs. They're painkillers that ease joint pain and swelling from psoriatic arthritis -- but they also can trigger psoriasis flare-ups. Naproxen and indomethacin are NSAIDs that have been linked to relapses of the skin condition.

    Other NSAIDs might also cause problems. Ask your doctor whether you can try a different kind of pain reliever, like acetaminophen.

    Mental Health Medicines

    Some drugs that treat mental health issues like depression and bipolar disorder can make your psoriasis worse. They include:

    • Fluoxetine (Prozac, Sarafem)
    • Lithium

    Some meds that treat anxiety, panic disorders, and sleep problems may affect your skin condition, too:

    • Alprazolam (Niravam, Xanax)
    • Clonazepam (Klonopin)
    • Diazepam (Valium)

    Your doctor can lower the dose of these medicines to see if that helps your psoriasis symptoms. Or, you may need to switch to other drugs.

    Heart Drugs

    If you have heart disease or a heart rhythm problem, you might take a medicine that's been linked to psoriasis flares. These include:

    • Amiodarone
    • Digoxin (Lanoxicaps, Lanoxin)
    • Gemfibrozil (Lopid)
    • Quinidine

    Ask your doctor if you can try another medicine to keep your heart healthy.

    Antimalarial Drugs

    If your plans include travel to southern Africa or another malaria-prone part of the world, you might need medicine to protect yourself against this mosquito-borne disease. But if you have psoriasis, these drugs can be a problem:

    • Chloroquine (Aralen)
    • Hydroxychloroquine (Plaquenil)


    Other Medicines That Could Trigger a Flare

    A few other drugs to discuss with your doctor include:

    • Antibiotics like tetracycline. They’re often used to treat infections like pneumonia.
    • Drugs called interferons. They help your body fight off viruses like hepatitis C.
    • Terbinafine (Lamisil, Terbinex). This medicine treats infections caused by a fungus, like jock itch or athlete's foot.


    WebMD Medical Reference