Understanding Psoriasis -- Treatment

What Are the Treatments for Psoriasis?

Despite the fact that psoriasis is incurable, it responds well to many topical and systemic treatments. Even people with severe psoriasis can get relief during flare-ups in about 85% to 90% of cases.

Topical Treatments for Psoriasis

Topical treatments are rubbed directly into the affected skin to bring local relief without the system-wide side effects of medicines taken by mouth. Topical treatments for psoriasis include:

Salicylic acid . Some doctors recommend salicylic acid ointment, which smoothes the skin by promoting the shedding of psoriatic scales. Using salicylic acid over large areas of skin, however, may cause the body to absorb too much of the medication, leading to side effects. Salicylic acid may also cause skin irritation and weaken hair shafts, which can cause breakage and temporary hair loss. The effectiveness of these preparations are modest at best.

Steroid-based creams. The mainstay of psoriasis treatment, steroid creams decrease inflammation, relieve itching, and block the production of cells that are overproduced in psoriasis. Stronger preparations, which are more effective than milder ones, can cause side effects that include burning, dryness, irritation, and thinning of the skin. Be especially careful to follow your doctor's instructions on their use.

Calcipotriene -containing topical ointment. Calcipotriene, which is related to vitamin D, has proven to be effective for treating psoriasis, especially when combined with a topical corticosteroid cream. It's best to use only limited amounts to avoid side effects.

Coal-tar ointments and shampoos. These products can help slow the rapid growth of skin cells and alleviate symptoms, but some people are vulnerable to the side effects, especially folliculitis, a pimple-like rash affecting the hair follicles. These medicines should be used only under a doctor's supervision.

Prescription retinoids. These topical preparations containing a synthetic form of vitamin A can help improve psoriasis. These preparations don't work as quickly as steroids. Topical retinoids can sometimes cause dryness and irritation of the skin.

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Light Therapy for Psoriasis

Even regular doses of sunlight -- not enough to produce sunburn -- can help psoriasis lesions in many people. For persistent, difficult-to-treat cases of psoriasis, many doctors recommend light therapy. One of the most effective treatments is PUVA (the drug psoralen combined with ultraviolet A, or UVA, light). However, this form of therapy is used far less often today, because it has been shown to increase the risk of developing skin cancer -- even decades after stopping this therapy.

Some doctors may prescribe ultraviolet B light (UVB) treatment using a light box alone or with other therapies such as coal tar. A more targeted ultraviolet light treatment, called narrow-band UVB therapy, is less carcinogenic than PUVA but almost as effective.

Oral Drugs for Psoriasis

When other treatments fail, some doctors prescribe oral drugs to treat psoriasis. Some of these medications affect the immune system. One such medication, methotrexate (also used as a chemotherapy drug for cancer and for various forms of arthritis), can produce dramatic clearing of the psoriasis lesions. However, it can cause side effects, so the prescribing doctor should perform regular blood tests. Another medication of this type is cyclosporine.

Oral retinoids, compounds with vitamin-A-like properties, can be mildly helpful to people with severe psoriasis. Women of childbearing age need to use birth control with this medication and for three years afterwards, because it is associated with increased risk for birth defects.

Newer treatments for people with severe psoriasis and psoriatic arthritis are now available. Several "biologic" drugs, which are made from human or animal proteins, focus on controlling the body's immune response. These drugs are quite effective but are extremely expensive and include etanercept (Enbrel), adalimumab (Humira) and ustekinumab (Stelara).

Natural Psoriasis Treatments

If medications fail to relieve the symptoms of psoriasis or cause unwanted side effects, people may try natural remedies, such as herbs and vitamins, for relief. Some people with psoriasis find natural sunlight and ocean water helpful. Some seaside resorts offer special programs for people with psoriasis.

If you are considering natural remedies for psoriasis, here's what you should know about some of the more commonly used remedies:

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Aloe vera. Preliminary research suggests that topical cream from the aloe vera plant may improve symptoms of psoriasis. One study showed that topical aloe vera was more effective than placebo. This product is of only minimal benefit, at best.

Fish oil. Fish oil may be helpful for psoriasis when taken orally. Research has suggested that taking daily oral fish oil supplements containing 1.8 to 3.6 grams of eicosapentaenoic acid (EPA) may bring some improvement.

Dead Sea salts. Bath solutions, such as Dead Sea salts, oil, oilated oatmeal, or Epsom salts can help psoriasis by removing scales and easing itching. To try Dead Sea salts and other bath solutions, mix them in the bath as directed, then soak in the tub for about 15 minutes. As soon as you get out of the tub, apply a moisturizer to the skin. Don't expect a lot of improvement, however.

Cayenne. Cayenne peppers have been used medicinally for thousands of years. Capsaicin, the ingredient in peppers that gives them their heat, is also the active ingredient in many pain-relieving gels and creams. In one study, applying capsaicin cream to the skin relieved itching and skin lesions in people with psoriasis. Capsaicin can cause a burning sensation to the skin, which improves the longer you use it. It's important to wash your hands immediately after rubbing in capsaicin and not touch your eyes or mouth while you have capsaicin on your hands.

Diet. Diet therapies are of almost no benefit in the treatment of psoriasis. Starvation has been shown to be associated with fewer symptoms, but this is hardly practical.

While natural remedies may play a role in psoriasis treatment, it's important to know that they, too, can have risks. You should never begin a new treatment -- even a natural one -- or stop a treatment prescribed by your doctor without first speaking with your doctor.

WebMD Medical Reference Reviewed by Debra Jaliman, MD on April 16, 2015

Sources

SOURCES:

National Psoriasis Foundation: "Over-the-counter (OTC) Topicals."

University of Maryland Medical Center: "Psoriasis -- Treatment."

University of Michigan Health System: "Psoriasis Topic Overview."

University of Maryland Medical Center: "Aloe."

University of Michigan Health System: "Psoriasis."

National Psoriasis Foundation: "Complementary approaches: natural elements."

National Cancer Institute: "Dictionary of Cancer Terms: Turmeric."

Kurd, S.K. Journal of the American Academy of Dermatology, April 2008.

 

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