The most common symptoms noted by people with PLMD are not leg movements but poor sleep and daytime sleepiness. Many people with PLMD are unaware of their leg movements unless their bed partner tells them.

Leg movements involve one or both limbs.

Typically the knee, ankle, and big toe joints all bend as part of the movements.
The movements vary from slight to strenuous and wild kicking and thrashing.
The movements last about 2 seconds (and thus are much slower than the leg jerks of myoclonus).
The movements are rhythmic and repetitive and occur every 20-40 seconds.

WebMD Medical Reference from eMedicineHealth

Reviewed by Leonard J. Sonne, MD on January 01, 2007

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Important Safety Information Full Prescribing Information

Real Migraines, Real People

Learn How TOPAMAX Can Help from Patients Who Have Been There

Important Safety Information | Prescribing Information

TOPAMAX is approved for migraine prevention in adults only.
TOPAMAX is not used to stop a migraine after it starts.

IMPORTANT SAFETY INFORMATION

Serious risks associated with TOPAMAX include lowered bicarbonate levels in the blood resulting in an increase in the acidity of the blood (metabolic acidosis). Symptoms could include hyperventilation (rapid, deep breathing), tiredness, loss of appetite, irregular heartbeat or changes in the level of alertness. Call your doctor immediately if you get these symptoms. Your doctor may want to do simple blood tests. Chronic, untreated metabolic acidosis may increase the risk for kidney stones or bone disease.

Other serious risks include decreased sweating, increased body temperature, kidney stones, sleepiness, dizziness, confusion, difficulty concentrating, and increased eye pressure (glaucoma). Call your doctor immediately if you have any decrease in vision or eye pain. These problems can lead to blindness if not treated right away.

More common side effects are tingling in arms and legs, loss of appetite, tiredness, nausea, diarrhea, taste change and weight loss.

Tell your doctor about other medications you take. Please see full U.S. Prescribing Information.

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