Strange itching, tingling, or "crawling" sensations occurring deep within the legs. These sensations sometimes occur in the arms.
A compelling urge to move the limbs to relieve these sensations
Restlessness - Floor pacing, tossing and turning in bed, rubbing the legs
Symptoms may occur only with lying or sitting. Sometimes persistent symptoms occur that are worse with lying or sitting and better with activity. In very severe cases, the symptoms may not improve with activity.

Other symptoms of RLS include the following:

Sleep disturbances and daytime sleepiness are very common.
Involuntary, repetitive, periodic, jerking limb movements occur either in sleep or while awake and at rest. These movements are called periodic leg movements of sleep or periodic limb movement disorder. About 80% of people with RLS also have this condition.

In some people with RLS, the symptoms do not occur every night but come and go. These people may go weeks or months without symptoms (remission) before the symptoms return again.

Reviewed by Michael W. Smith, MD on November 01, 2006

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Important Safety Information Full Prescribing Information

Real Migraines, Real People

Learn How TOPAMAX Can Help from Patients Who Have Been There

Important Safety Information | Prescribing Information

TOPAMAX is approved for migraine prevention in adults only.
TOPAMAX is not used to stop a migraine after it starts.

IMPORTANT SAFETY INFORMATION

Serious risks associated with TOPAMAX include lowered bicarbonate levels in the blood resulting in an increase in the acidity of the blood (metabolic acidosis). Symptoms could include hyperventilation (rapid, deep breathing), tiredness, loss of appetite, irregular heartbeat or changes in the level of alertness. Call your doctor immediately if you get these symptoms. Your doctor may want to do simple blood tests. Chronic, untreated metabolic acidosis may increase the risk for kidney stones or bone disease.

Other serious risks include decreased sweating, increased body temperature, kidney stones, sleepiness, dizziness, confusion, difficulty concentrating, and increased eye pressure (glaucoma). Call your doctor immediately if you have any decrease in vision or eye pain. These problems can lead to blindness if not treated right away.

More common side effects are tingling in arms and legs, loss of appetite, tiredness, nausea, diarrhea, taste change and weight loss.

Tell your doctor about other medications you take. Please see full U.S. Prescribing Information.

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