Skip to content
My WebMD Sign In, Sign Up

Sleep Disorders Health Center

Font Size

Rise and Shine: New Drug for Treatment of Daytime Sleepiness Caused by Narcolepsy

continued...

After nine weeks of treatment, the drug was stopped for 80% of the patients to see how stopping the medication would affect them -- if it would affect them.

During the two weeks following drug discontinuation, patients complained of feeling more sleepy, but no signs of amphetamine withdrawal syndrome -- such as sadness, fatigue, vivid unpleasant dreams, sleep changes, and increased appetite -- were apparent. This suggests that the treated patients had not become dependent on the drug.

"This is a very important addition to our [arsenal] for narcolepsy," says Gross, who is director of the sleep disorders center at the Lahey Clinic in Burlington, Mass., and was the lead investigator of the U.S. Modafinil in Narcolepsy Multicenter Group.

"This study demonstrates that modafinil is very efficient for most patients with narcolepsy without any noticeable side effects," says Seiji Nishino, MD, PhD, who reviewed the study for WebMD. "Because it's easy to use, we should see good compliance, especially because it produces few side effects. I think it will make a big difference [in the treatment of people with narcolepsy]." Nishino is associate director of the Center for Narcolepsy at Stanford University.

Gross says it is important to realize that although modafinil improved alertness in a profoundly sleepy population, it did not completely resolve all symptoms of excessive daytime sedation. He also warns that improvements in sleepiness may not occur until about three hours after taking the medication.

Nishino is quick to point out that traditional treatments may still be useful for narcolepsy, "[So] if modafinil doesn't work, we can still use the classical stimulants."

This study was funded by a grant from Cephalon Inc., the manufacturer of modafinil.

Vital Information:

  • Narcolepsy is an underdiagnosed condition that affects one out of 2,000 people and is characterized by excessive daytime sleepiness, sudden attacks in which sufferers are unable to move their bodies and therefore fall down, attacks of paralysis while trying to sleep, and hallucinations.
  • Researchers have found that the drug modafinil can help narcolepsy patients be less sleepy and stay awake longer with fewer negative side effects.
  • Currently, stimulants such as amphetamines are used to treat narcolepsy, but these are difficult to prescribe because of legal restrictions on the drugs.

1|2

Today on WebMD

Alcohol Disrupting Your Sleep
Article
Sweating Evaluator
Article
 
Lavender sprig
Article
Always Sleepy Causes Fixes For Fat
Slideshow
 

Is This Normal? Get the Facts Fast!

How Many Hours Did You Sleep Last Night?
Is that amount of sleep typical for you?
Did you get enough sleep to feel alert today and function at your best?

Get the latest Sleep Disorders newsletter delivered to your inbox!


or
Answer:
0-6
7-8
9+

Your level is currently

You say you are able to function well with fewer than seven hours of sleep. Some people say they can function on four to six hours of sleep each night, but research shows that adults who get fewer than seven hours of sleep — whether for just one night or over the course of days, weeks, or months — have more difficulty concentrating and more mood problems than people who sleep seven to nine hours.

Since you usually get too little sleep, please talk to your doctor about your sleep patterns. Poor quality sleep can affect many areas of your life and health, and your doctor may be able to help you if you have insomnia or other conditions affecting your sleep.

Sleep deprivation can have both short- and long-term consequences. Learn more about the health consequences of sleep loss. If you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

It's not surprising you feel that you're not functioning at your best today. Some people say they can function on four to six hours of sleep each night, but research shows that adults who get fewer than seven hours of sleep — whether for just one night or over the course of days, weeks, or months — have more difficulty concentrating and more mood problems than people who sleep seven to nine hours.

Since you usually get too little sleep, please talk to your doctor about your sleep patterns. Poor quality sleep can affect many areas of your life and health, and your doctor may be able to help you if you have difficulty sleeping, have insomnia, or have other sleep disorders.

Learn more about the health consequences of sleep loss. If you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

It's not surprising you feel that you're not functioning at your best today. Some people say they can function on four to six hours of sleep each night, but research shows that adults who get fewer than seven hours of sleep — whether for just one night or over the course of days, weeks, or months — have more difficulty concentrating and more mood problems than people who sleep seven to nine hours.

It's good that you usually do get more sleep, since sleep deprivation can have both short- and long-term consequences. Learn more about the health consequences of sleep loss. And if you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

You say you are able to function well with fewer than seven hours of sleep. Some people say they can function on four to six hours of sleep each night, but research shows that adults who get fewer than seven hours of sleep — whether for just one night or over the course of days, weeks, or months — have more difficulty concentrating and more mood problems than people who sleep seven to nine hours.

It's good that you usually do get more sleep because sleep deprivation can have both short- and long-term consequences. Learn more about the health consequences of sleep loss. And if you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

It's not surprising you feel that you're not functioning at your best today. Some people say they can function on four to six hours of sleep each night, but research shows that adults who get fewer than seven hours of sleep — whether for just one night or over the course of days, weeks, or months — have more difficulty concentrating and more mood problems than people who sleep seven to nine hours.

Since you usually get less sleep, please talk to your doctor about your sleep patterns. Poor quality sleep can affect many areas of your life and health, and your doctor may be able to help you if you have difficulty sleeping or have insomnia or other sleep disorders.

Learn more about the health consequences of sleep loss. If you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

It's wonderful that you got a good night's sleep last night. Many people struggle to do so. Having a good sleep routine often is the key to getting the quality sleep night after night that your body needs for optimal health. Whether your sleep routine involves taking a warm bath, reading a book, or meditating, it's important to keep your bedtime and routine consistent every night and wake up around the same time every morning.

Click here to read more about the importance of sleep. If you're concerned about having trouble falling asleep, staying asleep, or sleeping too much, assess your risk for a sleep disorder.

It's unfortunate you're not functioning at your best today. You say you had a good quantity of sleep last night, but maybe the quality of your sleep is not as good as it could be? Having a good sleep routine — including a consistent bedtime and wake time — often is the key to getting the quality sleep night after night that your body needs for optimal health. Since you usually sleep this amount, if you often aren't feeling your best, you should consider talking to your doctor. Could you have an underlying condition? Are you feeling anxious or depressed? Have you taken medication that disrupted your sleep? Do you or could you have sleep apnea? Or do you naturally require a little bit more sleep?

Although sleep is crucial for optimal health, some research suggests that sleeping too much can also have negative consequences. Learn more about sleep. If you're concerned about having trouble falling asleep, staying asleep, or sleeping too much, assess your risk for a sleep disorder.

It's unfortunate you're not functioning at your best today. You say you had a good quantity of sleep last night, but maybe the quality of your sleep is not as good as it could be? Having a good sleep routine — including a consistent bedtime and wake time — often is the key to getting the quality sleep night after night that your body needs for optimal health. Since you usually sleep longer, if you often aren't feeling your best, you should consider talking to your doctor. Could you have an underlying condition? Are you feeling anxious or depressed? Have you taken medication that disrupted your sleep? Do you or could you have sleep apnea? Or do you naturally require a little bit more sleep?

Although sleep is crucial for optimal health, some research suggests that sleeping too much can also have negative consequences. Learn more about sleep. If you're concerned about having trouble falling asleep, staying asleep, or sleeping too much, assess your risk for a sleep disorder.

It's wonderful that you got a good night's sleep last night. Many people struggle to do so. Having a good sleep routine often is the key to getting the quality sleep night after night that your body needs for optimal health. Whether your sleep routine involves taking a warm bath, reading a book, or meditating, it's also important to keep bedtime consistent and wake up around the same time every morning.

Although sleep is crucial for optimal health, some research suggests that sleeping too much can have negative consequences. Learn more about sleep. If you're concerned about having trouble falling asleep, staying asleep, or sleeping too much, assess your risk for a sleep disorder.

It's unfortunate you're not functioning at your best today. You say you had a good quantity of sleep last night, but maybe the quality of your sleep is not as good as it could be? Having a good sleep routine — including a consistent bedtime and waking up at the same time — often is the key to getting the quality sleep night after night that your body needs for optimal health.

Since you usually get less sleep, please talk to your doctor about your sleep patterns. Poor quality sleep can affect many areas of your life and health, and your doctor may be able to help you if you have insomnia, another sleep disorder, or conditions affecting your sleep.

Learn more about the health consequences of sleep loss. If you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

It's wonderful that you got a good night's sleep last night. Many people struggle to do so. Having a good sleep routine often is the key to getting the quality sleep night after night that your body needs for optimal health.

Since you usually get less sleep, talk to your doctor about your sleep patterns. Poor quality sleep can affect many areas of your life and health, and your doctor may be able to help you if you have insomnia or another sleep disorder or conditions affecting your sleep.

Learn more about the health consequences of sleep loss. If you're concerned about having trouble falling asleep or staying asleep, assess your risk for a sleep disorder.

SOURCES:

Centers for Disease Control and Prevention (CDC). Effect of short sleep duration on daily activities--United States, 2005-2008. MMWR Morb Mortal Wkly Rep 2011; 60:239.

Carskadon, MA, Dement, WC. Normal Human Sleep: An Overview. In: Principles and Practices of Sleep Medicine, Fifth, Kryger, MH, Roth, et al. (Eds), Elsevier Saunders, St. Louis, MO 2011. p.16.

Harvard University: "Sleep, Performance, and Public Safety."

Did You Know Lifestyle Choices
Impact Your Sleep?

Use the WebMD Sleep Tracker to track
your ZZZs over time.

Get Started

This tool is intended only for adults 18 and older.

Start Over

Step:  of 

Young woman sleeping
Quiz
Cannot sleep
Video
 
child sitting in bed
Article
Woman with insomnia
Quiz
 

nurse sleeping
ARTICLE
Foods That Help Or Harm Your Sleep
SLIDESHOW
 
Insomnia 20 Tips For Better Sleep
Slideshow
Pain at Night
ARTICLE