Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

Drugs for Periodic Limb Movement Disorder

Drugs do not cure periodic limb movement disorder (PLMD) but can relieve symptoms. Note that many of the medications used to treat PLMD are the same as those used to treat restless legs syndrome.

  • Benzodiazepines: These drugs suppress muscle contractions. They are also sedatives and help you sleep through the movements. Clonazepam (Klonopin), in particular, has been shown to reduce the total number of periodic limb movements per hour. It is probably the most widely used drug to treat PLMD.
  • Dopaminergic agents: These drugs increased the levels of an important neurotransmitter (brain chemical) called dopamine, which is important in regulating muscle movements. These medications seem to improve the condition in some people but not in others. Widely used examples are a levodopa/carbidopa combination (Sinemet) and pergolide (Permax).
  • Anticonvulsants: These drugs reduce muscle contractions in some people. The most widely used anticonvulsant in PLMD is gabapentin (Neurontin).
  • GABA agonists: These agents inhibit release of certain neurotransmitters that stimulate muscle contractions. The result is relaxation of contractions. The most widely used of these agents in PLMD is baclofen (Lioresal).


Recommended Related to Sleep Disorders

Do Seniors Need Less Sleep?

When it comes to myths about sleep, this one refuses to nod off -- and stay asleep. Contrary to popular opinion, older people don't need less sleep than the average person. In fact, adults require about the same amount of sleep from their 20s into old age, although the number of hours per night varies from person to person. But many older adults get much less sleep than they need, for a variety of reasons. Take Harry Gaertner, a 68-year-old retiree from Richardson, Texas. He remembers first being...

Read the Do Seniors Need Less Sleep? article > >

WebMD Medical Reference

Reviewed by Richard Senelick, MD on October 16, 2015

Today on WebMD

fatigued senior woman
We’ve got 10 tips to show you how
Man snoring in bed
Know your myths from your facts.
Young woman sleeping
What do your dreams say about you?
woman eith hangover
It’s common, and really misunderstood.
Young woman sleeping
Cannot sleep
child sitting in bed
Woman with insomnia
nurse sleeping
Foods That Help Or Harm Your Sleep
Insomnia 20 Tips For Better Sleep
Pain at Night