Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

Medications for REM Sleep Behavior Disorder

Clonazepam (Klonopin) is highly effective in the treatment of REM sleep behavior disorder (RBD), relieving symptoms in nearly 90% of patients with little evidence of tolerance or abuse. The response usually begins within the first week, often on the first night. The initial dose is 0.5 mg at bedtime, with some persons requiring a rapid increase to 1 mg. After years of continued treatment, moderate limb twitching with sleep talking and more complex behaviors can reemerge. The treatment should be continued for as long as your doctor says. If you decide to stop, the medicine should be slowly tapered, watching for signs of withdrawal such as nightmares or agitation.

Other drugs, such as tricyclic antidepressants, may be effective in some persons with RBD. However, tricyclics are also known to precipitate RBD in some patients.

Recommended Related to Sleep Disorders

How to Sleep With a Snorer

By Ellie McGrath Love can be blind and, for a while, even deaf. I was somewhat aware that my husband-to-be had a snoring problem, but I didn't realize the extent until a friend he had traveled with presented us with an unusual wedding present: a black collar studded with little electrodes. Whenever my husband snored, he'd get a harmless electric shock that would wake him him up — with the goal of conditioning him to stop snoring altogether. After a few nights, though, my husband called for...

Read the How to Sleep With a Snorer article > >

WebMD Medical Reference

Reviewed by Richard Senelick, MD on October 20, 2015

Today on WebMD

fatigued senior woman
We’ve got 10 tips to show you how
Man snoring in bed
Know your myths from your facts.
Young woman sleeping
What do your dreams say about you?
woman eith hangover
It’s common, and really misunderstood.
Young woman sleeping
Cannot sleep
child sitting in bed
Woman with insomnia
nurse sleeping
Foods That Help Or Harm Your Sleep
Insomnia 20 Tips For Better Sleep
Pain at Night