Sleeping Pills: What You Need to Know
From dependency risks to a.m. drowsiness, not all sleep aids work alike. Which is right for you?
Common Prescription Sleep Aids continued...
Because selective GABA medicines don't work on all the GABA receptors
throughout the brain, "they are thought to be relatively safer" than
benzodiazepines, the older drugs on which they're based, "with less addictive
potential," says Esther.
However, selective GABA medicines do have potential side effects, which are
usually mild and include:
- Memory disturbances
- Behavior changes prior to sleep
Ambien and other medicines in this class have also been blamed for episodes
of "confusional arousal" -- what most of us would call sleepwalking. In a few
well-publicized cases, people drove cars or wandered away from home after
taking the drugs. These cases represent only a tiny percentage of the number of
people who have taken these medicines, however.
The Latest Prescription Sleep Medicine
Sleep-wake cycle modifiers: Ramelteon (Rozerem) is the newest
prescription sleep medicine, and the only drug in its class. Ramelteon acts
directly on the body's sleep-wake cycle, or circadian rhythm.
The sleep-wake cycle is partially controlled by a part of the brain called
the hypothalamus. Ramelteon binds specifically to melatonin receptors in this
"circadian clock" area of the brain, promoting sleep. "This might be good for a
'night owl' trying to get to sleep for a new job," says Esther.
Because its activity is limited to one part of the brain, ramelteon has few
side effects compared to other medicines that act more generally. Its risk of
physical dependence is thought to be essentially zero. However, all sleep
medicines can cause psychological dependence.
Ramelteon also does not seem to have any potential for abuse, so it is not
controlled like benzodiazepines and selective GABA medicines such as Ambien,
Lunesta, or Sonata. So far, it has not been shown to cause hallucinations or
Studies show that ramelteon works well in older adults with chronic
insomnia. Because it acts on a part of the brain that controls hormones,
ramelteon may affect hormone levels if taken for extended periods. This can
reduce sex drive in men or make it harder for women to get pregnant.