Skip to content
My WebMD Sign In, Sign Up

Smoking Cessation Health Center

Font Size

Psychosocial Issues in Hereditary Colon Cancer Syndromes: Lynch Syndrome and Familial Adenomatous Polyposis

continued...

Colorectal screening for FAP

Less is known about psychological aspects of screening for FAP. One study of a small number of persons (aged 17-53 years) with a family history of FAP who were offered participation in a genetic counseling and testing protocol found that among those who were asymptomatic, all reported undergoing at least one endoscopic surveillance before participation in the study.[66] Only 33% (two of six patients) reported continuing screening at the recommended interval. Of the affected persons who had undergone colectomy, 92% (11 of 12 patients) were adherent to recommended colorectal surveillance. In a cross-sectional study of 150 persons with a clinical or genetic diagnosis of classic FAP or attenuated FAP (AFAP) and at-risk relatives, 52% of those with FAP and 46% of relatives at risk for FAP, had undergone recommended endoscopic screening.[69] Among persons who had or were at risk for AFAP, 58% and 33%, respectively, had undergone screening. Compared with persons who had undergone screening within the recommended time interval, those who had not screened were less likely to recall provider recommendations for screening, more likely to lack health insurance or insurance reimbursement for screening, and more likely to believe that they are not at increased risk for CRC. Only 42% of the study population had ever undergone genetic counseling. A small percentage of participants (14% to 19%) described screening as a "necessary evil," indicating a dislike for the bowel preparation, or experienced pain and discomfort. Nineteen percent reported that these issues might pose barriers to undergoing future endoscopies. Nineteen percent reported that improved techniques and the use of anesthesia have improved tolerance for screening procedures.

Risk-reducing surgery for FAP

When persons at risk of FAP develop multiple polyps, risk-reducing surgery in the form of subtotal colectomy or proctocolectomy is the only effective way to reduce the risk of CRC. Most persons with FAP can avoid a permanent ostomy and preserve the anus and/or rectum, allowing some degree of bowel continence. Studies of bowel function after subtotal colectomy show that patients average four to five stools per day in the immediate postoperative period, decreasing to three stools per day by 1 year postsurgery.[70]

With regards to behavioral or psychosocial outcomes, studies of risk-reducing surgery for FAP have found that general measures of quality of life have been within normal range, and the majority reported no negative impact on their body image.[71,72] However, other studies suggest that risk-reducing surgery for FAP may have negative quality-of-life effects for at least some proportion of those affected. Twenty-nine percent of FAP-affected persons who had undergone subtotal colectomy reported that increased stool frequency adversely affected their activities, and 14% reported occasional liquid soiling.[70] When FAP-specific quality-of-life domains were measured, one study indicated that persons undergoing ileal pouch anal anastomosis may experience more adverse outcomes for physical functioning, body image, sexual functioning, and negative affect compared with those who have not had surgery; and physical functioning and negative affect may be worse compared with persons who had an ileorectal anastomosis.[73] Another study showed that 20% of those with good bowel function nonetheless reported fears about incontinence that affected their quality of life.[74]

1|2|3|4|5|6|7|8|9|10|11|12|13|14|15|16|17

WebMD Public Information from the National Cancer Institute

Last Updated: May 16, 2012
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

Today on WebMD

Smoking and Heart Disease
ARTICLE
Ways Smoking Affects Looks
Slideshow
 
Putting out cigarette
USER REVIEWS
Woman smoking, close-up
Quiz
 

Are You at Risk for Dupuytrens Contracture
Article
Quit Smoking Aids
VIDEO
 
Lung Cancer Risks Myths and Facts
SLIDESHOW
man with inhaler
Quiz
 

Erectile Dysfunction
SLIDESHOW
How To Quit Smoking
VIDEO
 
person pouring water into mouth
SLIDESHOW
How You Can Control Blood Sugar and Manage Insulin
SLIDESHOW