Understanding Arthritis Painkillers
Weighing the Risks and Benefits

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Arthritis: Narcotic Pain Medication

WebMD Medical Reference

There are a variety of strong pain relievers, containing narcotic drugs, that your doctor may prescribe to help relieve your arthritis pain.

Often, these pain relievers are combined with acetaminophen (Tylenol). Theyinclude:

  • Tylenol with Codeine (acetaminophen with codeine)
  • Lorcet, Lortab, Vicodin (hydrocodone with acetaminophen)
  • Morphine
  • OxyContin, Roxicodone (oxycodone)
  • Percocet. (oxycodone with acetaminophen)
  • Darvon (propoxyphene)
  • Darvocet (propoxyphene with acetaminophen)

Side Effects

Alcohol and drugs containing acetaminophen or Tylenol don't mix. The combination can greatly increase your risk of severe liver damage.

When you take narcotic drugs, you also run the risk of developing adependence on the drugs. That means that you need more and more of the drugs inorder to get the same effect. Also, narcotic drugs can cause constipation, drowsiness, dry mouth, and difficulty urinating.

How Do Narcotics Relieve Pain?

Unlike ibuprofen, Motrin, Aleve, or other NSAID drugs, narcotic pain relievers do not decrease the inflammation that occurs with arthritis. Narcotic drugs work on pain receptors on nerve cells to relieve pain.

If you have pain that isn't relieved by a narcotic drug or NSAID alone, speak to your doctor about combining the two. In some cases, an NSAID/narcotic combination may relieve pain better than either alone.


Reviewed by the doctors at The ClevelandClinic Department of Rheumatic and Immunologic Diseases.

SOURCE: Arthritis Foundation

Edited by Marc C. Levesque, PhD, MD on February 01, 2007

Portions of this page © The Cleveland Clinic 2000-2005

What do you take for arthritis pain relief?

  • Over-the-counter pain relievers
  • Prescription painkillers
  • Alternative therapies
  • None of the above

Arthritis: Frequently Asked Questions

1. What causes arthritis pain?

2. How is arthritis pain treated?

3. What alternative therapies may relieve arthritis pain?

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