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    MELAS Syndrome

    Important
    It is possible that the main title of the report MELAS Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, Stroke-Like Episod
    • Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke

    Disorder Subdivisions

    • None

    General Discussion

    MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes) syndrome is a rare disorder that begins in childhood, usually between two and fifteen years of age, and mostly affects the nervous system and muscles. The most common early symptoms are seizures, recurrent headaches, loss of appetite and recurrent vomiting. Stroke-like episodes with temporary muscle weakness on one side of the body (hemiparesis) may also occur and this can lead to altered consciousness, vision and hearing loss, loss of motor skills and intellectual disability. MELAS is caused by mutations in mitochondrial DNA and in one patient, this syndrome has been associated with mutations in a nuclear gene, POLG1.

    Resources

    CLIMB (Children Living with Inherited Metabolic Diseases)
    Climb Building
    176 Nantwich Road
    Crewe, CW2 6BG
    United Kingdom
    Tel: 4408452412173
    Fax: 4408452412174
    Email: enquiries@climb.org.uk
    Internet: http://www.CLIMB.org.uk

    United Mitochondrial Disease Foundation
    8085 Saltsburg Road Suite 201
    Pittsburgh, PA 15239
    United States
    Tel: (412)793-8077
    Fax: (412)793-6477
    Tel: (888)317-8633
    Email: info@umdf.org
    Internet: http://www.umdf.org

    Lactic Acidosis Support Trust
    1A Whitley Close
    Middlewich
    Cheshire, CW10 0NQ
    United Kingdom
    Tel: 0160683719
    Fax: 01606837198

    Epilepsy Foundation
    8301 Professional Place
    Landover, MD 20785-7223
    Tel: (866)330-2718
    Fax: (877)687-4878
    Tel: (800)332-1000
    TDD: (800)332-2070
    Email: ContactUs@efa.org
    Internet: http://www.epilepsyfoundation.org

    Muscular Dystrophy Association
    3300 East Sunrise Drive
    Tucson, AZ 85718-3208
    USA
    Tel: (520)529-2000
    Fax: (520)529-5300
    Tel: (800)572-1717
    Email: mda@mdausa.org
    Internet: http://www.mda.org/

    NIH/National Institute of Neurological Disorders and Stroke
    P.O. Box 5801
    Bethesda, MD 20824
    Tel: (301)496-5751
    Fax: (301)402-2186
    Tel: (800)352-9424
    TDD: (301)468-5981
    Internet: http://www.ninds.nih.gov/

    Mitochondrial Disease Support Group Online
    5022 Michigan Avenue
    West Palm Beach, FL 33415
    Tel: (407)641-4712
    Email: madmolmom@gmail.com
    Internet: http://www.mitosupport.org/

    Vereniging voor Kinder met Stofwisselingsziekten
    P.O. Box 664
    Bloemendalstraat 11
    Zwolle, 8000 AR
    The Netherlands
    Tel: 0384201764
    Fax: 0384201447
    Email: info@stofwisselingsziekten.nl
    Internet: http://www.stofwisselingsziekten.nl

    Children's Mitochondrial Disease Network
    Mayfield House
    30 Heber Walk
    Chester Way
    Northwich
    England, CW9 5JB
    United Kingdom
    Tel: 440160643946
    Fax: 440160643946
    Email: info@cmdn.org.uk
    Internet: http://www.emdn-mitonet.co.uk/

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    MitoAction
    14 Pembroke Street
    Medford, MA 02155
    Tel: (888)648-6228
    Fax: (888)648-6228
    Email: info@mitoaction.org
    Internet: http://www.MitoAction.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 1/10/2011
    Copyright 1993, 1998, 1999, 2000, 2001, 2011 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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