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    Drug Trio May Cut Stroke Severity

    Too Soon to Recommend the Drug Mix, Researchers Caution
    WebMD Health News

    April 24, 2006 -- Strokes caused by blood clots may be less severe in patients taking three particular types of drugs.

    Those drug types -- antiplatelets, statins, and ACE inhibitors -- are already used to help prevent stroke in at-risk patients. Now, a new study shows that strokes tend to be less severe in patients taking all three drug types.

    Doctors from Harvard Medical School and Boston's Beth Israel Deaconess Hospital worked on the study, which appears in Neurology.

    "Our findings, although intriguing, are preliminary," write Sandeep Kumar, MD, and colleagues. However, they note that further studies are needed before recommending the drug trio for all patients at risk for stroke.

    Stroke Study

    Stroke is the No. 3 cause of death and a major cause of disability among U.S. adults. Every year, about 700,000 people in the U.S. have a stroke. That's one stroke every 45 seconds, on average, according to the American Stroke Association.

    The most common type of stroke is ischemic stroke, in which blood flow to the brain is blocked. Those blockages may be due to a stationary clot that forms in a blood vessel or by a clot that travels through the bloodstream and becomes lodged in a blood vessel.

    Kumar and colleagues studied 210 patients treated at the same hospital for ischemic stroke. All of the patients had arrived at the hospital within 24 hours of the start of stroke symptoms.

    Prompt treatment for stroke is a must, since some clot-busting stroke drugs must be given within a few hours of the start of stroke symptoms.

    Patients' Drugs

    Here is an overview of the three types of drugs noted in the study:

    • Antiplatelets prevent the formation of blood clots. Aspirin is the most common antiplatelet drug.
    • Statins lower LDL "bad" cholesterol. They also have other effects, such as clot blocking.
    • ACE inhibitors widen (dilate) blood vessels and increase blood flow.

    Before their stroke, 110 patients (52%) were taking an antiplatelet. That group included 47 patients who were only taking an antiplatelet, 29 taking an ACE inhibitor and an antiplatelet, 14 taking an antiplatelet and a statin, and 20 taking all three types of drugs.

    Aspirin was the most common type of antiplatelet taken by the patients. Roughly all groups were examined at the hospital within six hours of the start of stroke symptoms, the study shows.

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