Antibiotic May Help Treat Stroke
Minocycline May Be a Treatment for Stroke Patients Who Miss Treatment Window for Other Stroke Drugs
Oct. 2, 2007 -- The antibiotic minocycline may reduce stroke damage in some
Researchers report that news in today's edition of the journal
The finding comes from a study of 152 men and women in Israel who had a
stroke caused by a blood clot. Such strokes, called ischemic strokes, are the
most common type of stroke.
All of the patients in the Israeli study got to the hospital six to 24 hours
after their stroke symptoms started. That's too late for clot-busting stroke
drugs, which must be given within a few hours of the start of a stroke.
In addition to routine stroke care, half of the patients took minocycline
pills for five days. The other half of the group took pills containing no
The researchers -- who included Yair Lampl, MD, of Tel Aviv University --
followed the patients' progress for three months.
Improvements Seen After 1 Week
The patients who took minocycline fared better than those taking the placebo
pills throughout the study.
"The improvement was already apparent within a week of the stroke,"
Lampl says in an American Academy of Neurology news release.
"This is exciting," Lampl says, "because many people who have
had stroke cannot get to the hospital within three hours after symptoms start,
which is the timeframe for current available treatments" for ischemic
Lampl and colleagues speculate that minocycline may help ischemic stroke
patients by taming inflammation and by blocking cell death.
But minocycline didn't totally erase stroke damage, and it didn't affect the
patients' rate of death, heart attack, recurrent stroke, or bleeding.
The researchers call for larger studies to confirm the findings and to
identify the best dose of minocycline for treating ischemic stroke.
Meanwhile, swift stroke treatment is a must. That means getting emergency
medical care at the first sign of stroke symptoms.
The American Stroke Association lists these possible signs of stroke:
- Sudden numbness or weakness of the face, arm, or leg, especially on one
side of the body
- Sudden confusion and trouble speaking or understanding
- Sudden trouble seeing in one or both eyes
- Sudden trouble walking, dizziness, or loss of balance or coordination
- Sudden, severe headache with no known cause
Those symptoms may or may not be caused by a stroke, but the stakes are too
high to chance it, so seek treatment immediately.