Lipitor Linked to Bleeding After Stroke
Experts: Most Patients Still Benefit From Taking Lipitor
Who Should Take Statins? continued...
Schwamm is director of Acute Stroke Services at Massachusetts General
Hospital and a spokesman for the American Heart Association (AHA).
"The (treatment-associated) effect was small compared to these other
risks," he says.
He points out that only a small percentage of strokes -- about 17% according
to the AHA -- are caused by ruptured blood vessels leading to brain bleeding.
The rest, called ischemic strokes, occur when blood flow to the brain is
blocked, usually by a clot.
"People who have had hemorrhagic strokes are usually at risk for
ischemic stroke, so you can't say these people wouldn't benefit from this
treatment," he says. "The key message is that patients with a history
of hemorrhagic stroke should have a careful discussion with their doctor about
the risks and benefits of this treatment."
A spokeswoman for Lipitor manufacturer Pfizer Inc. agrees.
"It is important for patients to discuss their individual risk factors
with their doctor," Halit Bander, PhD, tells WebMD.
Can Cholesterol Be Too Low?
Goldstein says the latest analysis of the SPARCL results proved reassuring
in several ways.
Very low LDL cholesterol levels had been linked to an increased risk for
brain bleeds in several earlier, epidemiological studies.
"The hypothesis has been that we may be driving cholesterol too low with
treatment," he says. "But in this study we saw no association between
cholesterol lowering and brain hemorrhage."
And the data showed no evidence of an increase in brain bleeding linked to
the use of blood-thinning drugs.