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Incontinence & Overactive Bladder Health Center

Stem Cells May Help Treat Incontinence

Study Shows Benefit From Stem Cells Derived From a Patient's Muscle Cells
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Fat Cells Might Work, Too

A woman's fat cells may provide another treatment option someday, says Tom Lue, MD, a University of California San Francisco urologist. Using fat to strengthen sphincter muscles is not new, he says. But using stem cells from fat is.

"As far back as 1994, a study was published talking about using fat [injections] for sphincter incontinence," he says. "But using the fat cells [themselves], they die. But using stem cells, they survive much better."

In his study of the concept in animals, his team harvested fat tissue, processed it to retrieve the stem cells, and then injected it back into the animals. A comparison group only got a buffered solution; the treatment group received both the fat stem cells and the buffered solution.

He found that the stem cells became muscle tissue as well as blood vessel and fat tissues. And by using a person's own stem cells, Lue says, "we bypass immunology problems and ethical concerns."

Stem Cells From Urine, Cord Blood

While tissue biopsy is the most common way to obtain adult stem cells, another researcher reported that he isolated them from human urine. Anthony Atala, MD, a researcher at Wake Forest University in Winston-Salem, N.C., took urine samples from nine men and isolated and expanded the cells. He implanted them in mice and found they maintained their cellular characteristics. That suggests urine may someday be a valuable additional source for stem cells to help urinary problems.

Yet another research team is looking at human cord blood as a source of stem cells that might help urinary incontinence. In a study done in South Korea, Chester Koh, MD, a researcher at the University of Southern California, Los Angeles, and his colleagues injected human cord blood stem cells into 39 women with stress urinary incontinence.

After one month, 80% of the women reported a 50% or greater improvement in quality of life.

Estimated Time Line

As promising as some of the research to help stress urinary incontinence sounds, the studies are in "extremely early" stages, Roger Dmochowski, MD, the moderator of the press briefing on tissue engineering, tells WebMD.

When might the new treatments be available? "At the earliest, three years, more likely five to seven years," says Dmochowski, a urologist at Vanderbilt University in Nashville, Tenn., and the president of the Society for Female Urology and Urodynamics.

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