Skip to content
My WebMD Sign In, Sign Up

Incontinence & Overactive Bladder Health Center

Font Size

Botox May Put the Brakes on Overactive Bladder


WebMD Health News

Oct. 4, 2012 -- Injections of Botox may be as good as pills for putting the brakes on an overactive bladder.

Overactive bladder is marked by a sudden, uncontrollable urge to urinate, which can lead to the involuntary loss of urine, called urge incontinence. Botox works by relaxing the bladder muscle. It is already FDA-approved to treat urinary incontinence due to overactive bladder related to nerve damage from conditions such as multiple sclerosis and spine injury.

But doctors are allowed to use their own judgment to prescribe Botox "off-label" to treat overactive bladder from other causes.

Medications called anticholinergics are also used for overactive bladder. They work to relieve symptoms by relaxing the muscles of the bladder.

In a new study of nearly 250 women who had urge incontinence, a one-time Botox injection in the bladder worked as well as daily pills at reducing episodes of urinary incontinence at six months. Fully 70% of women in both groups reported an average of three leaks a day at the six-month mark compared to an average of five a day at the start of the study.

What’s more, twice as many women who received the Botox reported that their incontinence went away.

Still, much like with wrinkles, the effects of Botox on the bladder don’t last forever. Women will likely need another injection within nine months to a year to keep their bladder symptoms under control.

The findings are published in the Oct. 4, 2012, issue of the New England Journal of Medicine and being presented at the annual meeting of the American Urogynecologic Society in Chicago.

Botox, Medication Reduce Daily Leaks

“Both Botox and medicine reduced daily bladder leakage,” says researcher Anthony G. Visco, MD. He is the chief of the urogynecology and reconstructive pelvic surgery division at Duke University Medical Center in Durham, N.C. “Botox as another option and if it is FDA-approved for this, it will expand the choices that women have.”

If Botox gets broader FDA approval for overactive bladder, insurance will likely begin to cover the cost, which can be up to $1,000 per treatment.

Both the oral medications and the injections can have side effects. In the study, some women complained that the pills caused dry mouth, while the shot led to urine retention, and increased the chance of needing a catheter to drain the bladder. Twice the number of women in the Botox group got urinary tract infections compared to the pill group.

Botox injections to the bladder are performed in a doctor’s office and are not as painful as they sound, Visco says. Doctors often use a numbing agent as well. “Most women tolerate it very well and some don’t feel it at all.”

Today on WebMD

Incontinence Women Slideshow
SLIDESHOW
exam room
Slideshow
 
Public restroom door sign
Slideshow
nachos and beer
Article
 
woman holding water
Slideshow
Food That Makes You Gotta Go
Slideshow
 
Male Incontinence Slideshow
Slideshow
sleepless woman
Article
 
Worried in bed
Article
woman standing in front of restroom sign
Slideshow
 
woman reading medicine bottle
Quiz
Woman on riverbank in autumn
Slideshow