L-citrulline is a substance called a non-essential amino acid. Your kidneys change L-citrulline into another amino acid called L-arginine and a chemical called nitric oxide.
These compounds are important to your heart and blood vessel health. They may also boost your immune system.
Glutathione plays a role in many chemical reactions in your body. It also helps detoxify chemicals, including some that your body creates naturally, as well as pollutants and drugs.
Your supply of glutathione seems to decrease as you get older, possibly because your body can't create as much. Lower glutathione levels appear to go hand-in-hand with poorer health. For instance, lower levels may play a role in many conditions that are more likely to develop in older people.
Your glutathione levels may also decrease during certain health problems, such as:
People also take glutathione to try to treat weakened immune systems or infertility, as well as many other conditions.
Some studies show that glutathione may be effective for helping protect the body from the harmful effects of some cancer treatments. There is not enough research to support other uses for it.
Taking glutathione by mouth does not appear to be an effective way to get it into your body. In one study, giving healthy people 500 milligrams twice a day for a month didn't raise the level of glutathione in their blood.
Some other studies looking at its health effects have used it in injection form or as a treatment inhaled into the lungs.
Certain other supplements may boost your body's production of glutathione, such as:
Can you get glutathione naturally from foods?
Your body doesn't seem to absorb glutathione well from foods. However, certain foods high in amino acids that contain sulfur may help boost your levels. These include:
What are the risks of taking glutathione?
Side effects. Taking glutathione long-term has been linked to lower zinc levels. Inhaled glutathione may also trigger asthma attacks in people who have asthma. Symptoms may include wheezing.
Risks. Avoid taking glutathione if you're sensitive to it. Experts don't know if taking glutathione is safe during pregnancy and while breastfeeding.
Interactions. Tell your doctor about any supplements you're taking, even if they're natural. That way, your doctor can check on any potential side effects or interactions with any medications.