Skip to content

Find a Vitamin or Supplement

INDOLE - 3 - CARBINOL

Other Names:

3-Hydroxymethyl Indole, 3 Hydroxymethyl Indole, I3C, Indole 3 Carbinol, 3-(hydroxymethyl), 3-(hydroxyméthyl), 3 (hydroxymethyl) Indole, 3-Indolylcarbinol, 3 Indolylcarbinol, 3-Indolylmethanol, 3 Indolylmethanol, Indol-3-Carbinol, Indole, Indole ...
See All Names

INDOLE-3-CARBINOL Overview
INDOLE-3-CARBINOL Uses
INDOLE-3-CARBINOL Side Effects
INDOLE-3-CARBINOL Interactions
INDOLE-3-CARBINOL Dosing
INDOLE-3-CARBINOL Overview Information

Indole-3-carbinol is a substance found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. It can also be produced in the laboratory.

Indole-3-carbinol is used for prevention of breast cancer, colon cancer, and other types of cancer. The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is now sponsoring clinical research for breast cancer prevention.

Indole-3-carbinol is also used for fibromyalgia, tumors inside the voice box (laryngeal papillomatosis) caused by a virus, tumors inside the respiratory tract (respiratory papillomatosis) caused by a virus, abnormal cell growth in the cervix (cervical dysplasia), and systemic lupus erythematosus (SLE). Some people use indole-3-carbinol to balance hormone levels, “detoxify” the intestines and liver, and to support the immune system.

How does it work?

Researchers are interested in indole-3-carbinol for cancer prevention, particularly breast, cervical and endometrial, and colorectal cancer. Their reason is that diets with higher amounts of fruit and vegetable consumption are associated with a decreased risk of developing cancer. Researchers suspect indole-3-carbinol is one of several vegetable components that might protect against cancer.

INDOLE-3-CARBINOL Uses & Effectiveness What is this?

Possibly Effective for:

  • Abnormal development and growth of cells of the cervix (cervical dysplasia).

Insufficient Evidence for:

  • Respiratory papillomatosis. There is some evidence that long-term use of indole-3-carbinol might reduce tumor (papilloma) growth in patients with recurrent respiratory papillomatosis.
  • Laryngeal papillomatosis.
  • Prevention of breastcancer.
  • Coloncancer.
  • Fibromyalgia.
  • Systemic lupus erythematosus (SLE).
  • Hormone imbalances.
  • Other conditions.
More evidence is needed to rate the effectiveness of indole-3-carbinol for these uses.


INDOLE-3-CARBINOL Side Effects & Safety

Indole-3-carbinol is likely safe for most people when used in amounts typically found in the diet. It seems to be safe for most people when used in medicinal amounts under proper medical supervision. It can cause side effects such as skinrashes and small increases in liver enzymes.

In very high doses, indole-3-carbinol can cause balance problems, tremor, and nausea.

Special Precautions & Warnings:

Pregnancy and breast-feeding: If you are pregnant or breast-feeding, stick with indole-3-carbinol in amounts typically found in the diet. Not enough is known about the safety of using indole-3-carbinol in larger medicinal amounts.

INDOLE-3-CARBINOL Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with INDOLE-3-CARBINOL

    Some medications are changed and broken down by the liver.

    Indole-3-carbinol might increase how quickly the liver breaks down some medications. Taking indole-3-carbinol along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking indole-3-carbinol talk to your healthcare provider if you take any medications that are changed by the liver.

    Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.


INDOLE-3-CARBINOL Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For treating abnormal cells on the surface of the cervix (cervical dysplasia): 200-400 mg per day has been used. However, 200 mg seems to be as effective as the higher dose.

See 15 Reviews for this Treatment - OR -

Review this Treatment

Learn about User Reviews and read IMPORTANT information about user generated content

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

Search for a Vitamin or Supplement

Ex. Ginseng, Vitamin C, Depression

Today on WebMD

Woman taking a vitamin or supplement
Article
Man taking a vitamin or supplement
Article
 
clams
Quiz
Woman in sun
Slideshow
 
Flaxseed added fiber
Video
!!69X75_Vitamins_Supplements.jpg
Evaluator
 
Woman sleeping
Article
Woman staring into space with coffee
Article
 
IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.