HESPERIDIN Overview Information
Hesperidin is a plant chemical that is classified as a “bioflavonoid.” It is found primarily in citrus fruits. People use it as medicine.
Hesperidin alone, or in combination with other citrus bioflavonoids (diosmin, for example), is most often used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis). It is also used to treat lymphedema, a condition involving fluid retention that can be a complication of breast cancer surgery.
How does it work?
Hesperidin may help blood vessels function better. It may also reduce inflammation.
HESPERIDIN Uses & Effectiveness 
Possibly Effective for:
- Internal hemorrhoids, when used in combination with diosmin. The combination of hesperidin and diosmin seems to both significantly improve symptoms of hemorrhoids and also keep hemorrhoids, once healed, from coming back.
- Treating leg ulcers caused by poor circulation, when used in combination with diosmin. Hesperidin, in combination with diosmin and a compression dressing, seems to improve healing of small ulcers (less than 10 cm) caused by poor blood circulation.
Possibly Ineffective for:
- Reducing arm swelling in lymphedema following surgery for breast cancer.
Insufficient Evidence for:
- Varicose veins.
- Other conditions.
HESPERIDIN Side Effects & Safety
Hesperidin is POSSIBLY SAFE for most people when used for less than six months. The safety of using it for a longer period of time is unknown. Side effects include stomach pain and upset, diarrhea, and headache.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of hesperidin during pregnancy and breast-feeding. Stay on the safe side and avoid use.HESPERIDIN Interactions
We currently have no information for HESPERIDIN Interactions
HESPERIDIN Dosing
The following doses have been studied in scientific research:
BY MOUTH:
- For the treatment of hemorrhoids inside the anus: 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days.
- For preventing the return of hemorrhoids inside the anus: 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months.
- For the treatment of leg ulcers caused by poor blood circulation (venous stasis ulcers): a combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months.
