METHOXYLATED FLAVONES Overview Information
Flavonoids are pigments found in plants. They are responsible for many of the yellow, red, and orange colors in plants.
Over 4000 different flavonoids have been identified from various plant sources. Common food sources include red wine, stems, flowers, fruits, vegetables, nuts, seeds, herbs, spices, coffee, and teas.
In 1936, some scientists suggested that flavonoids be recognized as vitamins. They believed that flavonoids were necessary to protect the health of capillaries, the smallest blood vessels. But there wasn’t enough evidence to justify classifying flavonoids as vitamins.
Flavonoids are divided into groups based on slight differences in chemical structure. Flavones are one of the groups. Methoxylated flavones are a subdivision of that group. Methoxylated flavones are found in especially large amounts in citrus fruits.
Methoxylated flavones are used for poor circulation in the legs (venous insufficiency), varicose veins, heart disease, high cholesterol, cataracts, and cancer.
How does it work?
Methoxylated flavones are natural antioxidants and might reduce inflammation (swelling). They might also affect the way the liver processes cholesterol and other blood fats. Scientists think methoxylated flavones might also reduce the spread of cancer cells. But more information is needed.
METHOXYLATED FLAVONES Side Effects & Safety
Methoxylated flavones are a normal part of the diet. They are safe when consumed as part of food. But there isn’t enough information available to know if supplements containing methoxylated flavones are safe.
Special Precautions & Warnings:Pregnancy and breast-feeding: Methoxylated flavones are safe for pregnant and breast-feeding women when used as part of the diet. But the safety of methoxylated flavones during pregnancy and breast-feeding is not known when used in amounts greater than those commonly found in foods. It’s best to stay on the safe side and limit intake to food amounts.
Surgery: Methoxylated flavones can slow blood clotting. There is some concern that they might increase the risk of bleeding during and after surgery. Stop taking methoxylated flavones supplements at least 2 weeks before a scheduled surgery.
Moderate Interaction Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with METHOXYLATED FLAVONES
Some medications are changed and broken down by the liver.
Methoxylated flavones might increase how quickly the liver breaks down some medications. Taking methoxylated flavones along with some medications that are changed by the liver might decrease the effects of some medications. Before taking methoxylated flavones talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
- Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with METHOXYLATED FLAVONES
Some medications are moved by pumps in cells. Some methoxylated flavones might change how these pumps work and increase how much of some medications get absorbed by the body.
Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with METHOXYLATED FLAVONES
Some methoxylated flavones might slow blood clotting. Taking methoxylated flavones along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
METHOXYLATED FLAVONES Dosing
The appropriate dose of methoxylated flavones depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for methoxylated flavones. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.