My WebMD Sign In

Please enter email address

Enter your password

Keep me signed in on this computer

Show more Information

If you select "Keep me signed in on this computer", every time you visit WebMD.com you won't have to type your email address and password. This means that a cookie will stay on your computer even when you exit or close your browser which may reduce your levels of privacy and security. You should never select this option if you're using a publicly accessible computer, or if you're sharing a computer with others. Even if you select this option there are some features of our site that still require you to log in for privacy reasons.

Forget your password? Having trouble signing in?

Why should I
sign up for WebMD?

With a WebMD Account you can:

Track your way to weight loss success
Manage your family's vaccinations
Join the conversation

See more benefits Sign Up

Why WebMD?

My WebMD

Show Menu

Facebook Twitter Pinterest

Email a Friend

Print Article

WebMD Home

Vitamins & Supplements

D - MANNOSE

Other Names:

Carubinose, D-Manosa, Mannose, Seminose.

Review this Treatment 78 User Reviews See Brand Products

D-MANNOSE Overview Information

D-mannose is a kind of sugar that is related to glucose.

D-mannose is used for preventing urinary tract infections (UTIs) and treating carbohydrate-deficient glycoprotein syndrome, an inherited metabolic disorder.

How does it work?

D-mannose might treat the deficiency caused by a genetic defect that causes abnormal breakdown and production of mannose. D-mannose might prevent certain kinds of bacteria from sticking to the walls of the urinary tract and causing infection.

D-MANNOSE Uses & Effectiveness

Insufficient Evidence for:

Treating a rare inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b. Some reports suggest that taking D-mannose supplements improves protein loss, liver function, low blood sugar, and blood clotting disorders in people with this condition.
Preventing urinary tract infections (UTIs).
Other conditions.

More evidence is needed to rate the effectiveness of D-mannose for these uses.

D-MANNOSE Side Effects & Safety

D-mannose appears to be safe for most adults. It can cause loose stools and bloating. In high doses, it might harm the kidneys.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of D-mannose during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Diabetes: Some research suggests that D-mannose might make blood sugar control more difficult in people with diabetes.

D-MANNOSE Interactions

We currently have no information for D-MANNOSE Interactions

D-MANNOSE Dosing

The appropriate dose of D-mannose depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for d-mannose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View clinical references for this vitamin or supplement Sources

References:

Alton G, Hasilik M, Niehues R, et al. Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology 1998;8:285-95.

Davis JA, Freeze HH. Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse. Biochim Biophys Acta 2001;1528:116-26.

de Lonlay P, Cuer M, Vuillaumier-Barrot S, et al. Hyperinsulinemic hypoglycemia as a presenting sign in phosphomannose isomerase deficiency: A new manifestation of carbohydrate-deficient glycoprotein syndrome treatable with mannose. J Pediatr 1999;135:379-83.

Freinkel N, Lewis NJ, Akazawa S, et al. The honeybee syndrome - implications of the teratogenicity of mannose in rat-embryo culture. N Engl J Med 1984;310:223-30.

Hendriksz CJ, McClean P, Henderson MJ, et al. Successful treatment of carbohydrate deficient glycoprotein syndrome type 1b with oral mannose. Arch Dis Child 2001;85:339-40.

Michaels EK, Chmiel JS, Plotkin BJ, Schaeffer AJ. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Urol Res 1983;11:97-102 .

Niehues R, Hasilik M, Alton G, et al. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. J Clin Invest 1998;101:1414-20.

Ofek I, Goldhar J, Eshdat Y, Sharon N. The importance of mannose specific adhesins (lectins) in infections caused by Escherichia coli. Scand J Infect Dis Suppl 1982;33:61-7.

Ofek I, Mosek A, Sharon N. Mannose-specific adherence of Escherichia coli freshly excreted in the urine of patients with urinary tract infections, and of isolates subcultured from the infected urine. Infect Immun 1981;34:708-11.

Schaeffer AJ, Chmiel JS, Duncan JL, Falkowski WS. Mannose-sensitive adherence of Escherichia coli to epithelial cells from women with recurrent urinary tract infections. J Urol 1984;131:906-10.

Venegas MF, Navas EL, Gaffney RA, et al. Binding of type 1-piliated Escherichia coli to vaginal mucus. Infect Immun 1995;63:416-22.

Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85.

See 78 Reviews for this Treatment - OR -

Related to D-MANNOSE

Conditions & Treatments Related to D-MANNOSE

Carbohydrate-deficient glycoprotein syndrome type 1b Treatments

Learn about User Reviews and read IMPORTANT information about user generated content

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health acre professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

Vitamins & Supplements

Top Supplements

Drugs and Medications Center

Livng Healthy Resources

Article

Vitamin and Mineral Supplements for Women

Article

Vitamin and Mineral Supplements for Men

Quiz

Do You Get Enough Vitamin B12?

Slideshow

The Wonder Vitamin: Vitamin D

Article

Supplements for Sex Drive: Do They Work?

Evaluator

Vitamins and Supplements: Popping Too Many?

Article

About Sleep Herbs and Supplements

Article

St. John's Wort for Depression

Related Newsletters

Stay Informed with the latest must-read information delivered right to your inbox.

to WebMD Newsletters

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.