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SERRAPEPTASE

Other Names:

Butterfly Enzyme, Enzyme de Ver de Soie, Extrait de Ver de Soie, SER, Serratia peptidase, Serrapeptidase, Serratiopeptidase, Silk Worm Enzyme, Silkworm Extract.

SERRAPEPTASE Overview
SERRAPEPTASE Uses
SERRAPEPTASE Side Effects
SERRAPEPTASE Interactions
SERRAPEPTASE Dosing
SERRAPEPTASE Overview Information

Serrapeptase is a chemical taken from the silkworm. It is a commonly used drug (Takeda Chemical Industries) in Japan and Europe. In the U.S., serrapeptase is classified as a dietary supplement.

Serrapeptase is used for painful conditions including back pain, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, carpel tunnel syndrome, migraineheadache, and tension headache.

It is also used for conditions that involve pain and swelling (inflammation) including sinusitis, laryngitis, sore throat, ear infections, swelling after surgery, swelling of a vein with the formation of a blood clot (thrombophlebitis), and inflammatory bowel disease (IBD) including ulcerative colitis and Crohn's disease.

Some people use serrapeptase for heart disease and “hardening of the arteries” (atherosclerosis).

Women use it for non-cancerous lumpy breasts (fibrocystic breast disease), and nursing mothers use it for breast pain caused by too much milk (breast engorgement).

Other uses include treatment of diabetes, leg ulcers, asthma, and pus accumulation (empyema).

How does it work?

Serrapeptase helps the body break down protein. This might help decrease inflammation and mucous.

SERRAPEPTASE Uses & Effectiveness What is this?

Possibly Effective for:

  • Facial swelling after surgery to clear the sinuses.

Insufficient Evidence for:

  • Chronic bronchitis. Developing research suggests that serrapeptase can significantly reduce coughing and thin secretions in people with chronic bronchitis after about 4 weeks of treatment.
  • Sinus pain (sinusitis). Early research suggests that people with sinusitis who take serrapeptase have significantly reduced pain, nasal secretions, and nasal obstruction after 3-4 days of treatment.
  • Hoarseness (laryngitis). Early research suggests that serrapeptase can significantly reduce pain, secretions, difficulty swallowing, and fever in people with laryngitis after 3-4 days of treatment.
  • Sore throat (pharyngitis). Early research suggests that serrapeptase can significantly reduce pain, secretions, difficulty swallowing, and fever in people with sore throat after 3-4 days of treatment.
  • Back pain.
  • Osteoarthritis.
  • Rheumatoid arthritis.
  • Osteoporosis.
  • Carpel tunnel syndrome.
  • Diabetes.
  • Leg ulcers.
  • Migraine headache.
  • Tension headache.
  • Asthma.
  • Pus accumulation (empyema).
  • Thrombophlebitis.
  • Fibromyalgia.
  • Fibrocystic breast disease.
  • Inflammatory bowel disease (IBD) including ulcerative colitis and Crohn's disease.
  • Breast engorgement.
  • Heart disease.
  • Ear infections.
  • Other conditions.
More evidence is needed to rate the effectiveness of serrapeptase for these uses.


SERRAPEPTASE Side Effects & Safety

Serrapeptase seems to be safe for adults when taken by mouth, short-term (up to 4 weeks). The long-term safety of serrapeptase is not known.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of serrapeptase during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Serrapeptase might interfere with blood clotting, so some researchers worry that it might make bleeding disorders worse. If you have a bleeding disorder, check with your healthcare provider before using serrapeptase.

Surgery: Serrapeptase might interfere with blood clotting. There is a concern that it might increase bleeding during and after surgery. Stop using serrapeptase at least 2 weeks before a scheduled surgery.

SERRAPEPTASE Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs interacts with SERRAPEPTASE

    Serrapeptase might decrease blood clotting. Therefore, taking serrapeptase along with medications that also slow clotting might increase the chances of bruising and bleeding.
    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.


SERRAPEPTASE Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For reducing swelling of the inside of the cheek after sinus surgery: 10 mg of serrapeptase 3 times on the day before surgery, once in the evening after surgery, and then 3 times daily for 5 days following surgery.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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