Evodiamine (EVODIA) Overview Information
Evodia is a tree that is native to China and Korea. Evodia fruit, which has a strong bitter taste, is commonly used in Traditional Chinese Medicine. The fruit and root bark are also used as medicine in other herbal practice.
Evodia is used for digestion problems including diarrhea, dysentery, nausea, vomiting, abdominal pain, gastroesophageal reflux disease (GERD), stomach ulcers, and lack of appetite.
It is also used for obesity, headache, high blood pressure, congestive heart failure (CHF), infections caused by viruses, Alzheimer's disease, cancer, and fluid retention.
Women use evodia to prevent pregnancy, start their periods, and treat bleeding after giving birth.
Evodia root bark is used for infections caused by parasites such as tapeworm and pinworm.
How does it work?
Chemicals contained in evodia might have several effects in the body. They might decrease pain and swelling (inflammation), decrease diarrhea, decrease blood pressure, stimulate the heart, and have many other effects. But these effects have only been shown in animals. There is not enough information to know if evodia has these effects in people.
- Stomach pain.
- Lack of appetite.
- High blood pressure.
- Heart failure.
- Birth control.
- Lack of menstruation.
- Bleeding after giving birth.
- Infections caused by viruses.
- Infections caused by parasites.
- Stomach ulcers.
- Gastroesophageal reflux disease (GERD).
- Fluid retention.
- Alzheimer's disease.
- Other conditions.
Evodiamine (EVODIA) Side Effects & Safety
There is not enough information available to know if evodia is safe or what the possible side effects might be.
Special Precautions & Warnings:Pregnancy and breast-feeding: It might be UNSAFE to use evodia if you are pregnant. It contains some chemicals that affects pregnant animals. These chemicals cause the animals’ uterus to contract and also seem to reduce the size of the litter. It’s not known if evodia affects pregnant women, but it’s best to stay on the safe side and avoid use.
It’s also best to avoid using evodia if you are breast-feeding. Not enough is known about its effects.
Surgery: Evodia seems to slow blood clotting. There is a concern that it might increase the risk of bleeding during and after surgery. Stop using evodia at least 2 weeks before a scheduled surgery.
Moderate Interaction Be cautious with this combination
- Caffeine interacts with EVODIA
The body breaks down caffeine to get rid of it. Evodia might increase how quickly the body gets rid of caffeine. Taking evodia along with caffeine might decrease the effects of caffeine.
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with EVODIA
Some medications are changed and broken down by the liver. Evodia might increase how quickly the liver breaks down some medications. Taking evodia along with these medications might decrease how well the medications work.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with EVODIA
Some medications are changed and broken down by the liver. Evodia might decrease how quickly the liver breaks down some medications. Taking evodia along with these medications might increase the effects and side effects of these medications.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
- Medications that change the liver (Cytochrome P450 1A2 (CYP1A2) inhibitors) interacts with EVODIA
Some medications decrease how well the liver breaks down other medications. These medications that change the liver might decrease how fast chemicals in evodia are broken down in the body. This might increase the effects and side effects of evodia.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with EVODIA
Evodia might slow blood clotting. Taking evodia along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
- Theophylline interacts with EVODIA
The body breaks down theophylline to get rid of it. Evodia might increase how quickly the body gets rid of theophylline. Taking evodia along with theophylline might decrease the effectiveness of theophylline.
Evodiamine (EVODIA) Dosing
The appropriate dose of evodia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for evodia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.