LOTUS - Uses, Side Effects, and More

Ho, H. H., Hsu, L. S., Chan, K. C., Chen, H. M., Wu, C. H., and Wang, C. J. Extract from the leaf of nucifera reduced the development of atherosclerosis via inhibition of vascular smooth muscle cell proliferation and migration. Food Chem.Toxicol 2010;48(1):159-168. View abstract.

Huang, C. J. and Wu, M. C. Differential effects of foods traditionally regarded as 'heating' and 'cooling' on prostaglandin E(2) production by a macrophage cell line. J Biomed Sci 2002;9(6 Pt 2):596-606. View abstract.

Kuo, Y. C., Lin, Y. L., Liu, C. P., and Tsai, W. J. Herpes simplex virus type 1 propagation in HeLa cells interrupted by Nelumbo nucifera. J Biomed.Sci 2005;12(6):1021-1034. View abstract.

Li, M. and Xu, Z. Quercetin in a lotus leaves extract may be responsible for antibacterial activity. Arch.Pharm Res 2008;31(5):640-644. View abstract.

Li, M. Y. and Xu, Z. T. The inhibition of dentifrice containing the lotus leaf-derived inhibitor on periodontitis-related bacteria in vitro. Int.Dent.J 2007;57(5):303-306. View abstract.

Lin, M. C., Kao, S. H., Chung, P. J., Chan, K. C., Yang, M. Y., and Wang, C. J. Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf. J Agric.Food Chem. 7-8-2009;57(13):5925-5932. View abstract.

Mukherjee, P. K., Das, J., Saha, K., Giri, S. N., Pal, M., and Saha, B. P. Antipyretic activity of Nelumbo nucifera rhizome extract. Indian J Exp Biol 1996;34(3):275-276. View abstract.

Mukherjee, P. K., Saha, K., Balasubramanian, R., Pal, M., and Saha, B. P. Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract. J Ethnopharmacol. 1996;54(2-3):63-67. View abstract.

Mukherjee, P. K., Saha, K., Das, J., Pal, M., and Saha, B. P. Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Med 1997;63(4):367-369. View abstract.

Mukherjee, P. K., Saha, K., Pal, M., and Saha, B. P. Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol. 1997;58(3):207-213. View abstract.

Ohkoshi, E., Miyazaki, H., Shindo, K., Watanabe, H., Yoshida, A., and Yajima, H. Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Planta Med. 2007;73(12):1255-1259. View abstract.

Ono, Y., Hattori, E., Fukaya, Y., Imai, S., and Ohizumi, Y. Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol. 6-30-2006;106(2):238-244. View abstract.

Pan, Y., Cai, B., Wang, K., Wang, S., Zhou, S., Yu, X., Xu, B., and Chen, L. Neferine enhances insulin sensitivity in insulin resistant rats. J Ethnopharmacol. 7-6-2009;124(1):98-102. View abstract.

Sinha, S., Mukherjee, P. K., Mukherjee, K., Pal, M., Mandal, S. C., and Saha, B. P. Evaluation of antipyretic potential of Nelumbo nucifera stalk extract. Phytother Res 2000;14(4):272-274. View abstract.

Sohn, D. H., Kim, Y. C., Oh, S. H., Park, E. J., Li, X., and Lee, B. H. Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine. 2003;10(2-3):165-169. View abstract.

Talukder, M. J. and Nessa, J. Effect of Nelumbo nucifera rhizome extract on the gastrointestinal tract of rat. Bangladesh Med Res Counc.Bull 1998;24(1):6-9. View abstract.

Wang, J. L., Nong, Y., and Jing, M. X. [Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria]. Yao Xue.Xue.Bao. 1992;27(12):881-885. View abstract.

Xiao, J. H., Zhang, Y. L., Feng, X. L., Wang, J. L., and Qian, J. Q. Effects of isoliensinine on angiotensin II-induced proliferation of porcine coronary arterial smooth muscle cells. J Asian Nat.Prod.Res 2006;8(3):209-216. View abstract.

Yang, J. and Zhou, K. NMR spectroscopic analysis of neferine and isoliensinine. Magn Reson.Chem 2004;42(11):994-997. View abstract.

Yu, J. and Hu, W. S. [Effects of neferine on platelet aggregation in rabbits]. Yao Xue.Xue.Bao. 1997;32(1):1-4. View abstract.

Ahn Y, Kim S, Park C, Kim JE, Suh HJ, Jo K. Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors. Pharm Biol. 2022 Dec;60(1):1341-8. View abstract.

Baskaran R, Priya LB, Kalaiselvi P, Poornima P, Huang CY, Padma VV. Neferine from Nelumbo nucifera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells. Biomed Pharmacother. 2017;93:730-736. View abstract.

Cao J, Yu X, Deng Z, Pan Y, Zhang B, Tsao R, Li H. Chemical Compositions, Antiobesity, and Antioxidant Effects of Proanthocyanidins from Lotus Seed Epicarp and Lotus Seed Pot. J Agric Food Chem. 2018;66(51):13492-13502. View abstract.

He Y, Tao Y, Qiu L, et al. Lotus (Nelumbo nucifera Gaertn.) Leaf-Fermentation Supernatant Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Induced Obese Rats. Nutrients 2022;14(20):4348. View abstract.

Hiraguchi Y, Tokuda R, Gen M, et al. Identification of a novel food allergen in lotus root. Allergol Int. 2018;67(1):141-143. View abstract.

Khan S, Khan HU, Khan FA, et al. Anti-Alzheimer and Antioxidant Effects of Nelumbo nucifera L. Alkaloids, Nuciferine and Norcoclaurine in Alloxan-Induced Diabetic Albino Rats. Pharmaceuticals (Basel) 2022;15(10):1205. View abstract.

Paudel KR, Panth N. Phytochemical profile and biological activity of Nelumbo nucifera. Evid Based Complement Alternat Med. 2015;2015:789124. View abstract.

Pipil N, Gupta PP, Soni S, et al. Hypoglycemic Effect of Nelumbo Nucifera Seed Extract on GLUT-4 mRNA and GLUT-4 Protein in Streptozotocin-Induced Diabetic Rats. J Pharm Bioallied Sci 2023;15(Suppl 2):S1059-S1061. View abstract.

Sharma BR, Gautam LN, Adhikari D, Karki R. A comprehensive review on chemical profiling of Nelumbo nucifera: pPotential for drug development. Phytother Res. 2017;31(1):3-26. View abstract.

Sheck L, Wilson GA. Dry eye following ciguatera fish poisoning. Clin Exp Ophthalmol. 2010;38(3):315-7. View abstract.

Yanan Z, Lu M, Lu Z, Jinhai H, Weiming W. Effects and action mechanisms of lotus leaf (Nelumbo nucifera) ethanol extract on gut microbes and obesity in high-fat diet-fed rats. Front Nutr 2023;10:1169843. View abstract.

Ye L, Wang X, Konno T, et al. Fat reducing effects of Nelumbo nucifera leaf extract in overweight patients. Nat Prod Res. 2022 Sep;36(18):4776-81. View abstract.