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L - CITRULLINE

Other Names:

2-amino-5-(carbamoylamino)pentanoic acid, Citrulline, Citrulline Malate, L-Citrulina, L-Citrulline AKG, L-Citrulline-Alpha Ketoglutaric Acid, L-Citrulline Malate, Malate de Citrulline.

L-citrulline Overview
L-citrulline Uses
L-citrulline Side Effects
L-citrulline Interactions
L-citrulline Dosing
L-citrulline Overview Information

L-citrulline is a naturally occurring amino acid. It is found in some foods like watermelons and is also produced naturally by the body.

L-citrulline is used for Alzheimer’s disease, dementia, fatigue, muscle weakness, sickle cell disease, erectile dysfunction, high blood pressure, and diabetes. It is used for heart disease, body building, increasing energy, and for improving athletic performance.

How does it work?

L-citrulline is a naturally occurring amino acid found in food, such as watermelons, and also made in the body. Our bodies change L-citrulline into another amino acid called L-arginine and also to nitric oxide. L-citrulline might help increase the supply of ingredients the body needs to making certain proteins. It might also help open up veins and arteries to improve blood flow and reduce blood pressure.

L-citrulline Uses & Effectiveness What is this?

Insufficient Evidence for:

  • Exercise performance. L-citrulline might not be effective for improving exercise performance. In one research test, L-citrulline did not improve performance on a treadmill. People who took L-citrulline actually became exhausted more quickly than people who did not take it.
  • High blood pressure in children after heart surgery. L-citrulline might help reduce the high blood pressure that can occur after heart surgery in children. It’s given before and after the surgery.
  • Sickle cell disease. L-citrulline might improve some symptoms in people with sickle cell disease.
  • Other conditions.
More evidence is needed to rate the effectiveness of L-citrulline for these uses.


L-citrulline Side Effects & Safety

L-citrulline is POSSIBLY SAFE when used appropriately by adults and children.

Special Precautions & Warnings:

Pregnancy or breast-feeding: There is not enough reliable scientific information to know if L-citrulline is safe to take during pregnancy or while breast-feeding. Until more is known, avoid L-citrulline while you are pregnant or breast-feeding.

L-citrulline Interactions What is this?

We currently have no information for L-citrulline Interactions

L-citrulline Dosing

The appropriate dose of L-citrulline depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for L-citrulline. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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