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ALPHA - KETOGLUTARATE

Other Names:

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d’Arginine, Alpha-Cétoglutarate de Calcium, Alpha-Cétoglutarate de Créa...
See All Names

 Overview
 Uses
 Side Effects
 Interactions
 Dosing
Overview Information

Alpha-ketoglutarate is a chemical found in the body. People use it to make medicine.

Alpha-ketoglutarate is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.

Some people take alpha-ketoglutarate to improve peak athletic performance. Suppliers of athletic nutritional supplements claim alpha-ketoglutaric acid may be an important addition to proper diet and training for the athlete who wants peak performance. They base this claim on studies that show extra ammonia in the body can combine with alpha-ketoglutarate to reduce problems associated with too much ammonia (ammonia toxicity). But, so far, the only studies that show alpha-ketoglutarate can reduce ammonia toxicity have been performed in hemodialysis patients.

Healthcare providers sometimes give alpha-ketoglutarate intravenously (by IV) for preventing injury to the heart caused by blood flow problems during heart surgery and for preventing muscle breakdown after surgery or trauma.

How does it work?

Alpha-ketoglutarate works in many pathways in the body, to help make muscle, and to help heal wounds.

Uses & Effectiveness What is this?

Possibly Effective for:

  • Preventing blood supply problems during heart surgery, when given intravenously.
  • Preventing muscle breakdown after surgery or trauma, when added to a nutritional formula that is given intravenously.

Insufficient Evidence for:

  • Kidney disease.
  • Intestinal and stomach disorders.
  • Bacterial infections.
  • Yeast infections.
  • Improving athletic performance.
  • Improving protein usage in hemodialysis patients.
  • Cataracts.
  • Other conditions.
More evidence is needed to rate the effectiveness of alpha-ketoglutarate for these uses.


Side Effects & Safety

Alpha-ketoglutarate appears to be safe for most adults.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of alpha-ketoglutarate during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Interactions What is this?

We currently have no information for Interactions

Dosing

The following doses have been studied in scientific research:

INTRAVENOUS:

  • For preventing blood supply problems during heart surgery and for preventing muscle breakdown after surgery or trauma: healthcare providers give alpha-ketoglutarate intravenously (by IV).

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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