Overview
Syrian rue seeds contain chemicals called beta-carbolines. These chemicals cause many different effects in the body, such as stimulant effects and those that are similar to certain medicines used to treat Alzheimer disease.
People use Syrian rue for osteoarthritis, cancer, menstrual pain, and many other conditions, but there is no good scientific evidence to support these uses. It is also unsafe.
Uses & Effectiveness ?
We currently have no information for SYRIAN RUE overview.
Side Effects
When applied to the skin: Syrian rue is possibly safe when diluted in olive oil.
Special Precautions and Warnings
When applied to the skin: Syrian rue is possibly safe when diluted in olive oil.
Pregnancy and breast-feeding: Syrian rue is likely unsafe when taken by mouth during pregnancy or breast-feeding. Syrian rue can induce labor. It may also cause an abortion. Avoid use.
Heart conditions: Syrian rue contains the chemicals harmaline and harmine. These might cause complications in people who have a slow heart rate or heart disease.
Blockage in the stomach: Syrian rue contains the chemicals harmaline and harmine. These chemicals might cause complications in people who have a blockage in the stomach.
Liver disease: Liver damage has occurred in people who have taken Syrian rue. People with liver diseases, including hepatitis, should avoid taking Syrian rue.
Stomach ulcers: Syrian rue contains the chemicals harmaline and harmine. These chemicals might cause complications in people who have stomach ulcers.
Lung conditions: Syrian rue contains the chemicals harmaline and harmine. These chemicals might cause complications in people who have lung conditions, including asthma and chronic obstructive pulmonary disease (COPD).
Seizures: Syrian rue contains the chemicals harmaline and harmine. These chemicals might cause complications in people who have seizures.
Surgery: Syrian rue can affect levels of serotonin in the brain. This might interfere with surgical procedures. Discontinue Syrian rue use at least 2 weeks before a planned surgery.
Blockage in the urinary tract: Syrian rue contains the chemicals harmaline and harmine. These chemicals might cause complications in people who have a blockage in the urinary tract.
Interactions ?
Drying medications (Anticholinergic drugs) interacts with SYRIAN RUE
Syrian rue can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking Syrian rue might decrease the effects of anticholinergic drugs.
Caffeine interacts with SYRIAN RUE
Syrian rue contains a chemical called harmaline. Taking caffeine with harmaline might increase the risk for tremors.
Various medications used for glaucoma, Alzheimer disease, and other conditions (Cholinergic drugs) interacts with SYRIAN RUE
Syrian rue can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking Syrian rue with these medications might increase the chance of side effects.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with SYRIAN RUE
Some medications are changed and broken down by the liver. Syrian rue might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with SYRIAN RUE
Some medications are changed and broken down by the liver. Syrian rue might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications used for Parkinson disease (Dopamine agonists) interacts with SYRIAN RUE
Syrian rue contains chemicals that can affect the brain. These chemicals affect the brain similarly to some medications used for Parkinson disease. Taking Syrian rue with these medications might increase their effects and side effects.
Medications that can harm the liver (Hepatotoxic drugs) interacts with SYRIAN RUE
Syrian rue might harm the liver. Some medications can also harm the liver. Taking Syrian rue along with a medication that can harm the liver might increase the risk of liver damage.
Serotonergic drugs interacts with SYRIAN RUE
Syrian rue might increase a brain chemical called serotonin. Some medications also have this effect. Taking Syrian rue along with these medications might increase serotonin too much. This might cause serious side effects including heart problems, seizures, and vomiting.
Moderate Interaction
Be cautious with this combination
Dosing
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Li, Y., Sattler, R., Yang, E. J., Nunes, A., Ayukawa, Y., Akhtar, S., Ji, G., Zhang, P. W., and Rothstein, J. D. Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology 2011;60(7-8):1168-1175. View abstract.
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Ma, Y. and Wink, M. The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res 2010;24(1):146-149. View abstract.
Maestre, A., Balon, M., Munoz, M. A., Tejeda, P. O., and Sanchez, M. Determination of the dissociation constants of alkaloids from the family of Peganum harmala. Anales de la Real Academia de Farmacia (Spain) 1984;50:105-114.
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Mehta, H., Saravanan, K. S., and Mohanakumar, K. P. Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice. Behav Brain Res 2003;145(1-2):31-36. View abstract.
Meignin, C., Hilber, P., and Caston, J. Influence of stimulation of the olivocerebellar pathway by harmaline on spatial learning in the rat. Brain Res 1999;824(2):277-283. View abstract.
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Deecher, D. C., Teitler, M., Soderlund, D. M., Bornmann, W. G., Kuehne, M. E., and Glick, S. D. Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies. Brain Res 1992;571(2):242-247. View abstract.
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Derakhshanfar, A. and Mirzaei, M. Effect of Peganum harmala (wild rue) extract on experimental ovine malignant theileriosis: pathological and parasitological findings. Onderstepoort J Vet Res 2008;75(1):67-72. View abstract.
Derakhshanfar, A. and Mirzaei, M. Effect of Peganum harmala (wild rue) extract on experimental ovine malignant theileriosis: pathological and parasitological findings. Onderstepoort J Vet Res 2008;75(1):67-72. View abstract.
Di, Giorgio C., Delmas, F., Ollivier, E., Elias, R., Balansard, G., and Timon-David, P. In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Exp Parasitol 2004;106(3-4):67-74. View abstract.
Di, Giorgio C., Delmas, F., Ollivier, E., Elias, R., Balansard, G., and Timon-David, P. In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Exp Parasitol 2004;106(3-4):67-74. View abstract.
Durmaz Çelik N, Ger Akarsu F, Ozkan S, Özdemir AÖ, Aykac Ö, Memmedova F. Herbal teas can be harmful: a case of Peganum harmala induced coma in a patient with Parkinson's disease. Neurocase 2021;27(2):117-119. View abstract.
Durmaz Çelik N, Ger Akarsu F, Ozkan S, Özdemir AÖ, Aykac Ö, Memmedova F. Herbal teas can be harmful: a case of Peganum harmala induced coma in a patient with Parkinson's disease. Neurocase 2021;27(2):117-119. View abstract.
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Fan, B., Liang, J., Men, J., Gao, F., Li, G., Zhao, S., Hu, T., Dang, P., and Zhang, L. Effect of total alkaloid of Peganum harmala L. in the treatment of experimental haemosporidian infections in cattle. Trop Anim Health Prod 1997;29(4 Suppl):77S-83S. View abstract.
Fan, B., Liang, J., Men, J., Gao, F., Li, G., Zhao, S., Hu, T., Dang, P., and Zhang, L. Effect of total alkaloid of Peganum harmala L. in the treatment of experimental haemosporidian infections in cattle. Trop Anim Health Prod 1997;29(4 Suppl):77S-83S. View abstract.
Farouk, L., Laroubi, A., Aboufatima, R., Benharref, A., and Chait, A. Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. J.Ethnopharmacol 2008;115(3):449-454. View abstract.
Farouk, L., Laroubi, A., Aboufatima, R., Benharref, A., and Chait, A. Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. J.Ethnopharmacol 2008;115(3):449-454. View abstract.
Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., and Quevedo, J. Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus. J Neural Transm 2010;117(10):1131-1137. View abstract.
Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., and Quevedo, J. Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus. J Neural Transm 2010;117(10):1131-1137. View abstract.
Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., and Quevedo, J. Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties. Brain Res Bull 2010;81(4-5):491-496. View abstract.
Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., and Quevedo, J. Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties. Brain Res Bull 2010;81(4-5):491-496. View abstract.
Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., and Quevedo, J. Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(8):1425-1430. View abstract.
Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., and Quevedo, J. Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(8):1425-1430. View abstract.
Frison, G., Favretto, D., Zancanaro, F., Fazzin, G., and Ferrara, S. D. A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract. Forensic Sci Int 2008;179(2-3):e37-e43. View abstract.
Frison, G., Favretto, D., Zancanaro, F., Fazzin, G., and Ferrara, S. D. A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract. Forensic Sci Int 2008;179(2-3):e37-e43. View abstract.
Fuller, R. W., Wong, C. J., and Hemrick-Luecke, S. K. MD 240928 and harmaline: opposite selectivity in antagonism of the inactivation of types A and B monoamine oxidase by pargyline in mice. Life Sci 1986;38(5):409-412. View abstract.
Fuller, R. W., Wong, C. J., and Hemrick-Luecke, S. K. MD 240928 and harmaline: opposite selectivity in antagonism of the inactivation of types A and B monoamine oxidase by pargyline in mice. Life Sci 1986;38(5):409-412. View abstract.
Gaviraj, E. N, Babu, G. R., and Murthy, U. D. Antibacterial activity guided isolation of harmine from Peganum harmala seeds by bioautography. Indian Drugs 1998;35:471-474.
Gaviraj, E. N, Babu, G. R., and Murthy, U. D. Antibacterial activity guided isolation of harmine from Peganum harmala seeds by bioautography. Indian Drugs 1998;35:471-474.
Gerardy, J. Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline. Prog Neuropsychopharmacol Biol Psychiatry 1994;18(4):793-802. View abstract.
Gerardy, J. Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline. Prog Neuropsychopharmacol Biol Psychiatry 1994;18(4):793-802. View abstract.
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Ghizlane EA, Manal M, Ines HA, et al. Fatal poisoning of pregnant women by peganum harmala L.: a case reports. Ann Med Surg (Lond) 2021;68:102649. View abstract.
Gill, R. K., Kaur, J., Mahmood, S., Nagpaul, J. P., and Mahmood, A. Harmaline interactions with yeast invertase. Indian J Biochem Biophys 1998;35(2):86-90. View abstract.
Gill, R. K., Kaur, J., Mahmood, S., Nagpaul, J. P., and Mahmood, A. Harmaline interactions with yeast invertase. Indian J Biochem Biophys 1998;35(2):86-90. View abstract.
Hamsa, T. and Kuttan, G. Studies on anti-metastatic and anti-invasive effects of harmine using highly metastatic murine B16F-10 melanoma cells. J Environ Pathol Toxicol Oncol 2011;30(2):123-137. View abstract.
Hamsa, T. and Kuttan, G. Studies on anti-metastatic and anti-invasive effects of harmine using highly metastatic murine B16F-10 melanoma cells. J Environ Pathol Toxicol Oncol 2011;30(2):123-137. View abstract.
Hamsa, T. P. and Kuttan, G. Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chin Med 2011;6(1):11. View abstract.
Hamsa, T. P. and Kuttan, G. Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chin Med 2011;6(1):11. View abstract.
Hamsa, T. P. and Kuttan, G. Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. Eur J Pharmacol 2010;649(1-3):64-73. View abstract.
Hamsa, T. P. and Kuttan, G. Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. Eur J Pharmacol 2010;649(1-3):64-73. View abstract.
Harsh, M. L. and Nag, T. N. Antimicrobial principles from in vitro tissue culture of Peganum harmala. J Nat Prod 1984;47(2):365-367. View abstract.
Harsh, M. L. and Nag, T. N. Antimicrobial principles from in vitro tissue culture of Peganum harmala. J Nat Prod 1984;47(2):365-367. View abstract.
Herraiz, T., Gonzalez, D., Ancin-Azpilicueta, C., Aran, V. J., and Guillen, H. beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food Chem Toxicol 2010;48(3):839-845. View abstract.
Herraiz, T., Gonzalez, D., Ancin-Azpilicueta, C., Aran, V. J., and Guillen, H. beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food Chem Toxicol 2010;48(3):839-845. View abstract.
Hu, T., Fan, B., Liang, J., Zhao, S., Dang, P., Gao, F., and Dong, M. Observations on the treatment of natural haemosporidia infections by total alkaloid of Peganum harmala L. in cattle. Trop Anim Health Prod 1997;29(4 Suppl):72S-76S. View abstract.
Hu, T., Fan, B., Liang, J., Zhao, S., Dang, P., Gao, F., and Dong, M. Observations on the treatment of natural haemosporidia infections by total alkaloid of Peganum harmala L. in cattle. Trop Anim Health Prod 1997;29(4 Suppl):72S-76S. View abstract.
Ishida, J., Wang, H. K., Bastow, K. F., Hu, C. Q., and Lee, K. H. Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs. Bioorg Med Chem Lett 1999;9(23):3319-3324. View abstract.
Ishida, J., Wang, H. K., Bastow, K. F., Hu, C. Q., and Lee, K. H. Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs. Bioorg Med Chem Lett 1999;9(23):3319-3324. View abstract.
Iurlo, M., Leone, G., Schilstrom, B., Linner, L., Nomikos, G., Hertel, P., Silvestrini, B., and Svensson, H. Effects of harmine on dopamine output and metabolism in rat striatum: role of monoamine oxidase-A inhibition. Psychopharmacology (Berl) 2001;159(1):98-104. View abstract.
Iurlo, M., Leone, G., Schilstrom, B., Linner, L., Nomikos, G., Hertel, P., Silvestrini, B., and Svensson, H. Effects of harmine on dopamine output and metabolism in rat striatum: role of monoamine oxidase-A inhibition. Psychopharmacology (Berl) 2001;159(1):98-104. View abstract.
Javoy, F., Euvrard, C., Herbet, A., Bockaert, J., Enjalbert, A., Agid, Y., and Glowinski, J. Lack of involvement of dopaminergic and GABA neurones in the inhbitory effect of harmaline on the activity of striatal cholinergic neurones in the rat. Naunyn Schmiedebergs Arch Pharmacol 1977;297(3):233-239. View abstract.
Javoy, F., Euvrard, C., Herbet, A., Bockaert, J., Enjalbert, A., Agid, Y., and Glowinski, J. Lack of involvement of dopaminergic and GABA neurones in the inhbitory effect of harmaline on the activity of striatal cholinergic neurones in the rat. Naunyn Schmiedebergs Arch Pharmacol 1977;297(3):233-239. View abstract.
Javoy, F., Euvrard, C., Herbet, A., Bockaert, J., Enjalbert, A., Agid, Y., and Glowinski, J. Lack of involvement of dopaminergic and GABA neurones in the inhbitory effect of harmaline on the activity of striatal cholinergic neurones in the rat. Naunyn Schmiedebergs Arch Pharmacol 1977;297(3):233-239. View abstract.
Javoy, F., Euvrard, C., Herbet, A., Bockaert, J., Enjalbert, A., Agid, Y., and Glowinski, J. Lack of involvement of dopaminergic and GABA neurones in the inhbitory effect of harmaline on the activity of striatal cholinergic neurones in the rat. Naunyn Schmiedebergs Arch Pharmacol 1977;297(3):233-239. View abstract.
Jimenez, J., Riveron-Negrete, L., Abdullaev, F., Espinosa-Aguirre, J., and Rodriguez-Arnaiz, R. Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro. Exp Toxicol Pathol 2008;60(4-5):381-389. View abstract.
Jimenez, J., Riveron-Negrete, L., Abdullaev, F., Espinosa-Aguirre, J., and Rodriguez-Arnaiz, R. Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro. Exp Toxicol Pathol 2008;60(4-5):381-389. View abstract.
Jin, Y. J. [Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50]. Zhonghua Yan Ke Za Zhi 1990;26(5):286-288. View abstract.
Jin, Y. J. [Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50]. Zhonghua Yan Ke Za Zhi 1990;26(5):286-288. View abstract.
Kawanishi, K., Hashimoto, Y., Fujiwara, M., Kataoka, Y., and Ueki, S. Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice. J Pharmacobiodyn 1981;4(7):520-527. View abstract.
Kawanishi, K., Hashimoto, Y., Fujiwara, M., Kataoka, Y., and Ueki, S. Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice. J Pharmacobiodyn 1981;4(7):520-527. View abstract.
Kelly, D. M. and Naylor, R. J. Mechanisms of tremor induction by harmine. Eur J Pharmacol 1974;27(1):14-24. View abstract.
Kelly, D. M. and Naylor, R. J. Mechanisms of tremor induction by harmine. Eur J Pharmacol 1974;27(1):14-24. View abstract.
Kolasiewicz, W., Kuter, K., Nowak, P., Pastuszka, A., and Ossowska, K. Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. Cerebellum 2011;10(2):267-280. View abstract.
Kolasiewicz, W., Kuter, K., Nowak, P., Pastuszka, A., and Ossowska, K. Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. Cerebellum 2011;10(2):267-280. View abstract.
Lala, S., Pramanick, S., Mukhopadhyay, S., Bandyopadhyay, S., and Basu, M. K. Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems. J Drug Target 2004;12(3):165-175. View abstract.
Lala, S., Pramanick, S., Mukhopadhyay, S., Bandyopadhyay, S., and Basu, M. K. Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems. J Drug Target 2004;12(3):165-175. View abstract.
Lamchouri, F., Settaf, A., Cherrah, Y., Hassar, M., Zemzami, M., Atif, N., Nadori, E. B., Zaid, A., and Lyoussi, B. In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Fitoterapia 2000;71(1):50-54. View abstract.
Lamchouri, F., Settaf, A., Cherrah, Y., Hassar, M., Zemzami, M., Atif, N., Nadori, E. B., Zaid, A., and Lyoussi, B. In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Fitoterapia 2000;71(1):50-54. View abstract.
Lamchouri, F., Settaf, A., Cherrah, Y., Zemzami, M., Lyoussi, B., Zaid, A., Atif, N., and Hassar, M. Antitumour principles from Peganum harmala seeds. Therapie 1999;54(6):753-758. View abstract.
Lamchouri, F., Settaf, A., Cherrah, Y., Zemzami, M., Lyoussi, B., Zaid, A., Atif, N., and Hassar, M. Antitumour principles from Peganum harmala seeds. Therapie 1999;54(6):753-758. View abstract.
Liu CH, Chu WL, Liao SC, Yang CC, Lin CC. Syrian rue seeds interacted with acacia tree bark in an herbal stew resulted in N,N-dimethyltryptamine poisoning. Clin Toxicol (Phila) 2019;57(10):867-9. View abstract.
Liu CH, Chu WL, Liao SC, Yang CC, Lin CC. Syrian rue seeds interacted with acacia tree bark in an herbal stew resulted in N,N-dimethyltryptamine poisoning. Clin Toxicol (Phila) 2019;57(10):867-9. View abstract.
Lutes, J., Lorden, J. F., Beales, M., and Oltmans, G. A. Tolerance to the tremorogenic effects of harmaline: evidence for altered olivo-cerebellar function. Neuropharmacology 1988;27(8):849-855. View abstract.
Lutes, J., Lorden, J. F., Beales, M., and Oltmans, G. A. Tolerance to the tremorogenic effects of harmaline: evidence for altered olivo-cerebellar function. Neuropharmacology 1988;27(8):849-855. View abstract.
Ma, Y. and Wink, M. The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res 2010;24(1):146-149. View abstract.
Ma, Y. and Wink, M. The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res 2010;24(1):146-149. View abstract.
Mehta, H., Saravanan, K. S., and Mohanakumar, K. P. Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice. Behav Brain Res 2003;145(1-2):31-36. View abstract.
Mehta, H., Saravanan, K. S., and Mohanakumar, K. P. Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice. Behav Brain Res 2003;145(1-2):31-36. View abstract.
Meignin, C., Hilber, P., and Caston, J. Influence of stimulation of the olivocerebellar pathway by harmaline on spatial learning in the rat. Brain Res 1999;824(2):277-283. View abstract.
Meignin, C., Hilber, P., and Caston, J. Influence of stimulation of the olivocerebellar pathway by harmaline on spatial learning in the rat. Brain Res 1999;824(2):277-283. View abstract.
Meneguz, A., Betto, P., and Ricciarello, G. Different effects of harmine on plasma concentrations of L-dopa and on cerebral dopamine metabolism in rabbits and rats. Pharmacology 1994;48(6):360-366. View abstract.
Meneguz, A., Betto, P., and Ricciarello, G. Different effects of harmine on plasma concentrations of L-dopa and on cerebral dopamine metabolism in rabbits and rats. Pharmacology 1994;48(6):360-366. View abstract.
Mirzaei, M. Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala. Korean J Parasitol 2007;45(4):267-271. View abstract.
Mirzaei, M. Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala. Korean J Parasitol 2007;45(4):267-271. View abstract.
Mirzaiedehaghi, M. Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala. Onderstepoort J Vet Res 2006;73(2):153-155. View abstract.
Mirzaiedehaghi, M. Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala. Onderstepoort J Vet Res 2006;73(2):153-155. View abstract.
Monsef, H. R., Ghobadi, A., Iranshahi, M., and Abdollahi, M. Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. J Pharm Pharm Sci 2004;7(1):65-69. View abstract.
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Morcuende, S., Trigo, J. A., Delgado-Garcia, J. M., and Gruart, A. Harmaline induces different motor effects on facial vs. skeletal-motor systems in alert cats. Neurotox Res 2001;3(6):527-535. View abstract.
Morcuende, S., Trigo, J. A., Delgado-Garcia, J. M., and Gruart, A. Harmaline induces different motor effects on facial vs. skeletal-motor systems in alert cats. Neurotox Res 2001;3(6):527-535. View abstract.
Moroi, K., Takashi, K., and Kuga, T. Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats. Jpn J Pharmacol 1988;47(4):367-378. View abstract.
Moroi, K., Takashi, K., and Kuga, T. Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats. Jpn J Pharmacol 1988;47(4):367-378. View abstract.
Nenaah, G. Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia 2010;81(7):779-782. View abstract.
Nenaah, G. Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia 2010;81(7):779-782. View abstract.
Pinner, E., Padan, E., and Schuldiner, S. Amiloride and harmaline are potent inhibitors of NhaB, a Na+/H+ antiporter from Escherichia coli. FEBS Lett 1995;365(1):18-22. View abstract.
Pinner, E., Padan, E., and Schuldiner, S. Amiloride and harmaline are potent inhibitors of NhaB, a Na+/H+ antiporter from Escherichia coli. FEBS Lett 1995;365(1):18-22. View abstract.
Pitre, S. and Srivastava, S. K. Two New Anthraquinones from the Seeds of Peganum harmala. Planta Med 1987;53(1):106-107. View abstract.
Pitre, S. and Srivastava, S. K. Two New Anthraquinones from the Seeds of Peganum harmala. Planta Med 1987;53(1):106-107. View abstract.
Sacher, J., Houle, S., Parkes, J., Rusjan, P., Sagrati, S., Wilson, A. A., and Meyer, J. H. Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study. J Psychiatry Neurosci 2011;36(6):375-382. View abstract.
Sacher, J., Houle, S., Parkes, J., Rusjan, P., Sagrati, S., Wilson, A. A., and Meyer, J. H. Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study. J Psychiatry Neurosci 2011;36(6):375-382. View abstract.
Seifert, A., Allan, L. A., and Clarke, P. R. DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. FEBS J 2008;275(24):6268-6280. View abstract.
Seifert, A., Allan, L. A., and Clarke, P. R. DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. FEBS J 2008;275(24):6268-6280. View abstract.
Shahverdi, A. R., Monsef-Esfahani, H. R., Nickavar, B., Bitarafan, L., Khodaee, S., and Khoshakhlagh, N. Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds. Z Naturforsch C 2005;60(9-10):707-710. View abstract.
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Sharaf, M., el-Ansari, M. A., Matlin, S. A., and Saleh, N. A. Four flavonoid glycosides from Peganum harmala. Phytochemistry 1997;44(3):533-536. View abstract.
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Yuruktumen, A., Karaduman, S., Bengi, F., and Fowler, J. Syrian rue tea: a recipe for disaster. Clin Toxicol (Phila) 2008;46(8):749-752. View abstract.
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Zhao, T., He, Y. Q., Wang, J., Ding, K. M., Wang, C. H., and Wang, Z. T. Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives. Phytother Res 2011;25(11):1671-1677. View abstract.
Zhao, T., He, Y. Q., Wang, J., Ding, K. M., Wang, C. H., and Wang, Z. T. Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives. Phytother Res 2011;25(11):1671-1677. View abstract.
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