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GLUCOMANNAN

Other Names:

Amorphophallus konjac, Amorphophallus rivieri, Glucomanano, Glucomannane, Konjac, Konjac Mannan.

GLUCOMANNAN Overview
GLUCOMANNAN Uses
GLUCOMANNAN Side Effects
GLUCOMANNAN Interactions
GLUCOMANNAN Dosing
GLUCOMANNAN Overview Information

Glucomannan is a sugar made from the root of the konjac plant (Amorphophallus konjac). Glucommanan powder, capsules, and tablets are used as medicine.

Glucomannan is used for constipation, weight loss in adults and children, type 2 diabetes, blood sugar control, and lowering cholesterol.

In foods, glucomannan is used as a thickener or gelling agent. Glucommanan flour and powder are used in food.

How does it work?

Glucomannan might work in the stomach and intestines by absorbing water to form a bulky fiber which treats constipation. It may also slow the absorption of sugar and cholesterol from the gut, helping to control sugar levels in diabetes, and reducing cholesterol levels.

GLUCOMANNAN Uses & Effectiveness What is this?

Possibly Effective for:

  • Constipation. Research suggests that taking glucomannan by mouth can relieve constipation in children and adults.
  • Diabetes. Taking glucomannan by mouth seems to reduce cholesterol, bloodsugar levels, and blood pressure in people with diabetes.
  • High cholesterol. Taking glucomannan by mouth seems to improve cholesterol levels in people with high cholesterol, with or without diabetes.

Insufficient Evidence for:

  • Stomach condition called gastric dumping syndrome. Some early research suggests that taking a specific glucomannan product (Propol, Pharmacia, Woerden, The Netherlands) reduces the risk of blood sugar becoming too low after eating in people who have had stomach surgery. However, not all research agrees. Some research suggests that glucomannan does not improve blood sugar absorption in children after stomach surgery.
  • High blood pressure. Some early research suggests that glucomannan might improve blood pressure in people with high blood pressure.
  • Overactive thyroid (hyperthyroidism). Early research suggests that glucomannan plus methimazole and propranolol reduce thyroid hormone levels in people with too much thyroid hormone in the body.
  • Obesity. There is early research that suggests taking glucomannan by mouth might improve weight loss in overweight and obese adults and children. However, not all research agrees.
  • Other conditions.
More evidence is needed to rate glucomannan for these uses.


GLUCOMANNAN Side Effects & Safety

Glucomannan powder or flour is LIKELY SAFE when consumed as food. Glucomannan powder and capsules are POSSIBLY SAFE for most adults and children when used in medicinal amounts for up to 4 months. However, solid tablets containing glucomannan are POSSIBLY UNSAFE for adults and LIKELY UNSAFE for children. These can sometimes cause blockages of the throat or intestines.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking glucomannan if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Glucomannan may interfere with blood sugar control. Monitor blood sugar closely if you have diabetes and use glucomannan.

Surgery: Glucomannan might interfere with blood sugar control during and after surgery. Stop using glucomannan at least 2 weeks before a scheduled surgery.

GLUCOMANNAN Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications for diabetes (Antidiabetes drugs) interacts with GLUCOMANNAN

    Glucomannan can decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking glucomannan along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

  • Medications taken by mouth (Oral drugs) interacts with GLUCOMANNAN

    Glucomannan absorbs substances in the stomach and intestines. Taking glucomannan along with medications taken by mouth can decrease how much medicine your body absorbs, and decrease the effectiveness of your medication. To prevent this interaction, take glucomannan at least one hour after medications you take by mouth.


GLUCOMANNAN Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For type 2 diabetes with high cholesterol: 3.6 to 10.6 grams of glucomannan per day.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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