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LORENZO'S OIL

Other Names:

13-Docosenoic Acid, cis-9-Octadecenoic Acid, Aceite de Lorenzo, Acide Érucique, Acide Oléique, Erucic Acid, Glycerol Trierucate Oil, Glycerol Trioleate Oil, Huile de Lorenzo, Huile de Trioléate de Glycérol, Oleic Acid.

LORENZO'S OIL Overview
LORENZO'S OIL Uses
LORENZO'S OIL Side Effects
LORENZO'S OIL Interactions
LORENZO'S OIL Dosing
LORENZO'S OIL Overview Information

Lorenzo’s oil is a combination of two chemicals called erucic acid and oleic acid. People use Lorenzo’s oil as a medicine.

Lorenzo’s oil is used as a treatment for two related inherited conditions that affect the nervous system. These very rare conditions are called adrenoleukodystrophy (ALD), which occurs in children; and adrenomyeloneuropathy, which occurs in adults.

Lorenzo’s oil is named after a child, Lorenzo Odone, who developed ALD. His parents discovered a mixture of fatty acids that seemed to slow progression of the disease. The mixture became known as “Lorenzo’s oil.”

In the US, Lorenzo’s oil is only available to patients participating in a clinical trial. For more information, contact the Kennedy Krieger Institute at 1-800-873-3377.

There is currently an effort to obtain Food and Drug Administration (FDA) approval of Lorenzo’s oil as a prescription drug.

How does it work?

Adrenoleukodystrophy and adrenomyeloneuropathy are two rare genetic disorders that cause a large build-up of certain chemicals called very long-chain fatty acids. Lorenzo’s oil might help prevent some of this build-up. The build-up of these fatty acids is thought to cause many serious problems throughout the brain and body.

LORENZO'S OIL Uses & Effectiveness What is this?

Possibly Effective for:

  • Adrenoleukodystrophy (ALD). Lorenzo’s oil might help prevent nervous system problems in children who have ALD, but haven’t yet shown any symptoms. Lorenzo’s oil probably does not help children who already have symptoms of ALD.

Possibly Ineffective for:

  • Adrenomyeloneuropathy. Taking Lorenzo’s oil does not seem to improve symptoms or slow the progression of disease in patients with adrenomyeloneuropathy.

LORENZO'S OIL Side Effects & Safety

Lorenzo’s oil seems to be safe when used under the care of health professionals. Side effects of Lorenzo’s oil can include bruising and bleeding.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of Lorenzo’s oil during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Blood disorders that cause a decrease in blood platelets needed for clotting (thrombocytopenia) or a decrease in white cells needed to fight infections (neutropenia): Lorenzo’s oil might make these conditions worse.

LORENZO'S OIL Interactions What is this?

We currently have no information for LORENZO'S OIL Interactions

LORENZO'S OIL Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For adrenoleukodystrophy (ALD): a dose of Lorenzo’s oil that provides about 20% of daily calories has been used. In another study, 300 mg/kg/day of erucic acid and 1.7 grams/kg/day of oleic acid (both contained in Lorenzo’s oil) were used.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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