cis-resveratrol (RESVERATROL) Overview Information
Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine.
People use resveratrol for “hardening of the arteries” (atherosclerosis), lowering “bad” (LDL) cholesterol levels, increasing “good” (HDL) cholesterol levels, and preventing cancer.
How does it work?
Resveratrol might expand blood vessels and reduce the activity of cells important in blood clotting. Some research suggests that resveratrol has weak estrogen (a female hormone) effects. It may also decrease pain and swelling (inflammation).
- Acne. Early evidence shows that applying a gel containing resveratrol to the face might reduce the severity of acne.
- Lung disease (chronic obstructive pulmonary disease, COPD). Early research suggests that taking a combination product containing resveratrol, vitamin C, zinc, and flavonoids slightly reduces coughing and mucus production in people with COPD.
- Diabetes. Some research suggests that taking 5 mg of resveratrol twice daily for 4 weeks does not affect insulin levels in people with diabetes. However, other evidence shows that taking a specific product that contains resveratrol (Biofort) daily for 3 months reduces blood sugar, blood pressure and fat levels in the blood.
- “Hardening of the arteries” (atherosclerosis).
- High cholesterol.
- Preventing cancer.
- Other conditions.
cis-resveratrol (RESVERATROL) Side Effects & Safety
Resveratrol is LIKELY SAFE when used in the amounts found in foods, and when taken by mouth in doses up to 250 mg daily for up to 3 months. Higher doses of up to 900 mg have been taken for up to 2 days. Resveratrol has also been applied to the skin safely for up to 30 days.
Special Precautions & Warnings:Pregnancy and breast-feeding: Resveratrol is LIKELY SAFE when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol during pregnancy and breast-feeding.
Bleeding disorders: Resveratrol might slow blood clotting. In theory, resveratrol might increase the risk of bleeding in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use resveratrol.
Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.
Moderate Interaction Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver.
Resveratrol might decrease how quickly the liver breaks down some medications. Taking resveratrol along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking resveratrol, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with RESVERATROL
Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
cis-resveratrol (RESVERATROL) Dosing
The appropriate dose of resveratrol depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for resveratrol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.