Skip to content
My WebMD Sign In, Sign Up

Find a Vitamin or Supplement

IPRIFLAVONE

Other Names:

FL-113, 7-isopropoxyisoflavone, 7-Isopropoxy-Isoflavone, Ipriflavona, TC-80.

IPRIFLAVONE Overview
IPRIFLAVONE Uses
IPRIFLAVONE Side Effects
IPRIFLAVONE Interactions
IPRIFLAVONE Dosing
IPRIFLAVONE Overview Information

Ipriflavone is made in the laboratory from another substance (daidzein) that is taken from soy. Soy is a plant.

Ipriflavone is used for preventing and treating weak bones (osteoporosis) in older women, preventing osteoporosis caused by certain medications, relieving pain associated with osteoporosis, and treating a bone disease called Paget's disease. It is also used for reducing bone loss caused by chronic kidney disease (renal osteodystrophy) and by paralysis associated with stroke. Researchers have found that paralyzed stroke patients have weaker bones on the affected side, possibly due to immobility as well as vitamin D deficiency. Vitamin D deficiency may stem from lack of exposure to sunlight.

Ipriflavone is also used by bodybuilders to increase metabolism.

How does it work?

Ipriflavone may prevent bone strength loss, and help improve the effects of estrogen in preventing osteoporosis. When used in combination with estrogens, it might allow lower estrogen doses to be used in postmenopausal women.

IPRIFLAVONE Uses & Effectiveness What is this?

Likely Effective for:

  • Treating and preventing weak bones (osteoporosis) in postmenopausal women. Taking ipriflavone in combination with 1000 mg of calcium daily can prevent loss of bone mineral density (BMD) in postmenopausal women with osteoporosis or low bone strength. There is some evidence that it might actually increase bone strength in some of these women. The effect seems to be determined by the amount of calcium that is taken along with the ipriflavone. One study using ipriflavone with only 500 mg per day of calcium found no effect on bone strength. But taking more than 1000 mg of calcium daily may increase the benefit.
    Taking ipriflavone in combination with estrogen also seems to prevent osteoporosis and increase bone strength in older women. Adding calcium makes the combination work even better.
  • Reducing pain associated with osteoporosis. Ipriflavone can also significantly reduce pain due to osteoporosis and seems to be as effective as inhaling a medication called calcitonin.
  • Reducing bone loss in people who have been paralyzed on one side of their body by stroke (hemiplegic stroke). Ipriflavone in combination with vitamin D seems to prevent bone loss significantly better than vitamin D alone in hemiplegic stroke patients with vitamin D deficiency.

Possibly Effective for:

  • Bone pain in people with Paget's disease.
  • Bone disease due to chronic kidney disease (renal osteodystrophy).

Insufficient Evidence for:

  • Increasing metabolism in bodybuilders.
  • Other conditions.
More evidence is needed to rate the effectiveness of ipriflavone for these uses.


IPRIFLAVONE Side Effects & Safety

Ipriflavone is LIKELY SAFE for most people when used with proper medical supervision. It can cause side effects such as stomach pain, diarrhea, or dizziness.

There is some concern that ipriflavone can cause a decreased white cell count (lymphocytopenia) in people taking it for greater than six months. White cell counts should be monitored, especially in people taking ipriflavone long-term.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of ipriflavone during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Weak immune system: Ipriflavone can lower the body’s white cell count, making it more difficult for the body to fight off infection. This is especially concerning in people who already have a weak immune system due to AIDS, drugs used to prevent organ rejection after transplant, chemotherapy, or other causes. If you have a weak immune system, check with your healthcare provider before starting ipriflavone.

Low white cell count (lymphocytopenia): Since ipriflavone can cause lymphocytopenia, there is a concern that it might make pre-existing lymphocytopenia worse.

IPRIFLAVONE Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with IPRIFLAVONE

    Some medications are changed and broken down by the liver.
    Ipriflavone might decrease how quickly the liver breaks down some medications. Taking ipriflavone along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking ipriflavone talk to your healthcare provider if you take any medications that are changed by the liver.
    Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

  • Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with IPRIFLAVONE

    Some medications are changed and broken down by the liver.
    Ipriflavone might decrease how quickly the liver breaks down some medications. Taking ipriflavone along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking ipriflavone talk to your healthcare provider if you take any medications that are changed by the liver.
    Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.

  • Medications that decrease the immune system (Immunosuppressants) interacts with IPRIFLAVONE

    Ipriflavone might decrease the immune system. Taking ipriflavone along with other medications that decrease the immune system might decrease the immune system too much. Avoid taking ipriflavone with medications that decrease the immune system.
    Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

  • Theophylline interacts with IPRIFLAVONE

    The body breaks down theophylline to get rid of it. Ipriflavone might decrease how quickly the body gets rid of theophylline. Taking ipriflavone along with theophylline might increase the effects and side effects of theophylline.


IPRIFLAVONE Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For weak bones after menopause (postmenopausal osteoporosis): 200 mg of ipriflavone three times daily.
  • For a bone disorder called Paget's disease: 600-1200 mg of ipriflavone daily.
  • For treating weak bones due to kidney disease (renal osteodystrophy): 400-600 mg of ipriflavone daily.

See 2 Reviews for this Treatment - OR -

Review this Treatment

Learn about User Reviews and read IMPORTANT information about user generated content

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

Search for a Vitamin or Supplement

Ex. Ginseng, Vitamin C, Depression

Today on WebMD

Woman taking a vitamin or supplement
Article
Man taking a vitamin or supplement
Article
 
clams
Quiz
Woman in sun
Slideshow
 
Flaxseed added fiber
Video
!!69X75_Vitamins_Supplements.jpg
Evaluator
 
Woman sleeping
Article
Woman staring into space with coffee
Article
 
Related Newsletters

Stay Informed with the latest must-read information delivered right to your inbox.

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.