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PYRUVATE

Other Names:

2-Oxopropanoate, 2-Oxopropanoic acid, 2-Oxypropanoic Acid, Acetylformic Acid, Acide Acétylformique, Acide Alpha-Kéto, Acide Oxo-2 Propanoïque, Acide Pyruvique, Alpha-Keto Acid, Alpha-Ketopropionic Acid, Calcium Pyruvate, Calcium Pyruvate Monohyd...
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PYRUVATE Overview
PYRUVATE Uses
PYRUVATE Side Effects
PYRUVATE Interactions
PYRUVATE Dosing
PYRUVATE Overview Information

The body produces pyruvate when it breaks down sugar (glucose). Pyruvate is available as a supplement.

Pyruvate is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.

Some people apply pyruvic acid, a liquid form of pyruvate, to the skin to reduce wrinkles and other signs of aging. Pyruvic acid is sometimes applied to the skin as a facial peel.

How does it work?

Pyruvate might contribute to weight loss by increasing the breakdown of fat.

In addition, pyruvic acid seems to cause the outer layer of skin cells to slough off, which accounts for its use in reversing aging due to exposure to the sun.

PYRUVATE Uses & Effectiveness What is this?

Possibly Effective for:

  • Aging skin. Applying a 50% pyruvic acid skin peel once a week for 4 weeks seems to smooth skin, decrease fine wrinkles, and decrease dark spots associated with aging due to sun exposure.

Insufficient Evidence for:

  • Weight loss and obesity. So far, study results disagree about the effectiveness of pyruvate for weight loss.
  • Improving athletic performance. Some research suggests that taking pyruvate along with high-dose dihydroxyacetone from the diet increases arm and leg exercise endurance. However, other research suggests that pyruvate, alone or in combination with creatine does not improve athletic performance.
  • Cataracts.
  • Cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of pyruvate for these uses.


PYRUVATE Side Effects & Safety

Pyruvate seems to be safe when taken by mouth short-term (up to six weeks). Side effects such as stomach upset, gas, bloating, and diarrhea can occur when large amounts are taken.

Pyruvic acid facial peels seem to be safe when applied by a healthcare professional. It can cause severe skin burning and should be applied only to small patches of skin at a time.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of pyruvate during pregnancy and breast-feeding. Stay on the safe side and avoid use.

A heart condition called cardiomyopathy: One death was associated with intravenous use in a child who had cardiomyopathy.

PYRUVATE Interactions What is this?

We currently have no information for PYRUVATE Interactions

PYRUVATE Dosing

The following doses have been studied in scientific research:

APPLIED TO THE SKIN:

  • For aging skin: A 50% pyruvic acid peel applied once weekly for 4 weeks.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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