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Other Names:

Acides Gras Cetylated, Acides Gras Cétylés, Acides Gras Estérisés, Acides Gras Mono-Insaturés Cétylés, Ácidos Grasos Cetilados, Cerasomal-cis-9-cetylmyristoleate, Cetyl Laureate, Cetyl Myristate, Cetyl Myristoleate, Cetyl Oleate, Cetyl Palmitate...
See All Names

CETYLATED FATTY ACIDS Overview Information

Cetylated fatty acids are a group of naturally occurring fats. They include cetyl myristoleate, cetyl myristate, cetyl palmitoleate, cetyl laureate, cetyl palmitate, and cetyl oleate. Cetyl myristoleate receives the most attention. Many products that contain cetyl myristoleate also contain a mixture of these other cetylated fatty acids.

There is an interest in cetyl myristoleate for osteoarthritis because it is a substance found in certain mice that do not develop arthritis, even when researchers try to cause arthritis in the laboratory. Cetylated fatty acids are also used for other types of arthritis including rheumatoid arthritis (RA), osteoarthritis (OA), Reiter's syndrome, and ankylosing spondylitis.

Cetylated fatty acids are also used for diseases in which the body attacks itself (autoimmune diseases) including Sjogren's syndrome, systemic lupus erythematosus (SLE), and multiple sclerosis (MS).

Some people use cetylated fatty acids for psoriasis, fibromyalgia, emphysema, benign prostatic hyperplasia (BPH), silicone breast disease, various types of back pain, leukemia and other cancers, and a disease that involves inflammation of the blood vessels called Behcet's syndrome.

Cetylated fatty acids are applied to the skin for osteoarthritis.

How does it work?

Cetylated fatty acids might help lubricate joints and muscles, soften tissues, and increase flexibility. It also might help the immune system and reduce inflammation (swelling).

CETYLATED FATTY ACIDS Uses & Effectiveness What is this?

Possibly Effective for:

  • A type of arthritis called osteoarthritis, when taken by mouth or applied to the skin over the affected joint. Taking a specific blend of cetylated fatty acids (Celadrin, Proprietary Nutritionals, Inc.) combined with soy lecithin and fish oil by mouth seems to decrease pain and improve knee range of motion and function in people with knee osteoarthritis. However, this combination does not appear to improve morning stiffness. Applying the same specific blend of cetylated fatty acids directly to the skin either alone or in combination with menthol also seems to decrease pain and improve function in patients with knee osteoarthritis.

Insufficient Evidence for:

  • Rheumatoid arthritis.
  • Systemic lupus erythematosus (SLE).
  • Multiple sclerosis.
  • Reiter's syndrome.
  • Behcet's syndrome.
  • Sjogren's syndrome.
  • Psoriasis.
  • Fibromyalgia.
  • Emphysema.
  • Benign prostatic hyperplasia (BPH).
  • Silicone breast disease.
  • Leukemia and other cancers.
  • Various types of back pain.
  • Other conditions.
There isn’t enough evidence to rate the effectiveness of cetylated fatty acids for these uses.


Cetylated fatty acids are POSSIBLY SAFE when taken by mouth or applied to the skin, short-term. Side effects have not been reported. But there is not much information available about the safety of long-term use.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of cetylated fatty acids during pregnancy and breast-feeding. Stay on the safe side and avoid use.

CETYLATED FATTY ACIDS Interactions What is this?

We currently have no information for CETYLATED FATTY ACIDS Interactions


The following doses have been studied in scientific research:


  • For osteoarthritis: 350 mg of a specific blend of cetylated fatty acids (Celadrin, Proprietary Nutritionals, Inc.) plus 50 mg of soy lecithin, and 75 mg of fish oil taken 6 times daily.
  • For osteoarthritis, a specific blend of cetylated fatty acids (Celadrin, Proprietary Nutritionals, Inc.) applied twice daily to the affected joint.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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