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MSM METHYLSULFONYLMETHANE Overview Information
MSM is a chemical found in plants, animals, and humans. It can also be made in a laboratory. People use it as a medicine.
MSM is used for chronic pain, arthritis, joint inflammation, rheumatoid arthritis, osteoporosis, bursitis, tendonitis, tenosynovitis, musculoskeletal pain, muscle cramps, scleroderma, scar tissue, stretch marks, wrinkles, protection against sun/wind burn, eye inflammation, oral hygiene, periodontal disease, wounds, cuts, and abrasions/accelerated wound healing. It is either taken by mouth or applied to the skin for these uses. You may have heard about MSM because of the book The Miracle of MSM: The Natural Solution for Pain. There isn’t much published scientific research to support its use.
MSM is also used for relief of allergies, chronic constipation, “sour stomach,” ulcers, a bowel disease called diverticulosis, premenstrual syndrome (PMS), mood elevation, obesity, poor circulation, high blood pressure, and high cholesterol. It is also used for type 2 diabetes, liver problems, Alzheimer’s disease, lung disorders including emphysema and pneumonia, chronic fatigue syndrome, auto-immune disorders (systemic lupus erythematous), HIV infection and AIDS, and cancer (breast cancer and colon cancer).
Other uses of MSM include eye inflammation, mucous membrane inflammation, temporomandibular joint (TMJ) problems, leg cramps, migraine, headaches, hangover, parasitic infections of the intestinal and urogenital tracts including Trichomonas vaginalis and Giardia, yeast infections, insect bites, radiation poisoning, and to boost the immune system.
MSM is also used to control snoring. In fact, directions for making MSM nose drops for snoring have been published, but there’s no evidence that MSM has any effect on snoring.
Contrary to some MSM promotional literature, there is no Recommended Dietary Allowance (RDA) for MSM or sulfur, which it contains. Sulfur deficiency has not been described in the medical literature.
How does it work?
MSM might supply sulfur to make other chemicals in the body.
MSM METHYLSULFONYLMETHANE Uses & Effectiveness 
Possibly Effective for:
- Osteoarthritis. Taking MSM by mouth seems to slightly reduce some symptoms of arthritis, such as pain and joint movement, but it might not reduce other symptoms such as stiffness.
Insufficient Evidence for:
- Hay fever. One research study suggests MSM taken by mouth might relieve some symptoms of hay fever. However, this study has been criticized because it didn’t report on pollen counts or the seriousness of allergy symptoms. More research is needed.
- Chronic pain.
- Muscle and bone problems.
- Snoring.
- Allergies.
- Scar tissue.
- Stretch marks.
- Wrinkles.
- Protection against sun/wind burn.
- Eye swelling.
- Dental disease.
- Wounds.
- Asthma.
- Stomach upset.
- Constipation.
- Premenstrual syndrome (PMS).
- Mood elevation.
- Obesity.
- Poor circulation.
- High blood pressure.
- High cholesterol.
- Type 2 diabetes.
- Other conditions.
MSM METHYLSULFONYLMETHANE Side Effects & Safety
MSM is POSSIBLY SAFE for most people when taken by mouth for 3 months or less. In some people, MSM might cause nausea, diarrhea, bloating, fatigue, headache, insomnia, itching, or worsening of allergy symptoms.
There isn’t enough information to know if MSM is safe when applied to the skin, as in creams, lotions, or nose drops.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the safety of using MSM during pregnancy and breast-feeding. Stay on the safe side and avoid use.MSM METHYLSULFONYLMETHANE Interactions
We currently have no information for MSM METHYLSULFONYLMETHANE Interactions
MSM METHYLSULFONYLMETHANE Dosing
- For osteoarthritis: 500 mg three times daily up to 3 grams twice daily.
